NP_003677.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
exonuclease 1 isoform a
NCBI Official Synonym Full Names
exonuclease 1
NCBI Official Synonym Symbols
NCBI Protein Information
exonuclease 1
UniProt Protein Name
Exonuclease 1
UniProt Synonym Protein Names
Exonuclease I; hExoI
UniProt Synonym Gene Names
NCBI Summary for EXO1
This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for EXO1
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Research Articles on EXO1
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Products associated with anti-EXO1 antibody
Pathways associated with anti-EXO1 antibody
Diseases associated with anti-EXO1 antibody
Organs/Tissues associated with anti-EXO1 antibody
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