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anti-EXOSC5 antibody :: Rabbit anti-Human EXOSC5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7002295
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EXOSC5, Polyclonal Antibody

★Popular Item★
 Also Known As   

EXOSC5 Antibody

 Product Synonym Names    Exosome complex component RRP46; EXOSC5; CML28; RRP46; Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B
 Product Gene Name   

anti-EXOSC5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606492
 3D Structure    ModBase 3D Structure for Q9NQT4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity Purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Exosome complex component RRP46 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-131154
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EXOSC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EXOSC5 antibody

   Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
 Applications Tested/Suitable for anti-EXOSC5 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-EXOSC5 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-EXOSC5 antibody    Western blot
All lanes: EXOSC5 antibody at 5ug/ml
Lane 1:K562 whole cell lysate
Lane 2:293T whole cell lysate
Lane 3:Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 25kDa
Observed band size: 25kDa

anti-EXOSC5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-EXOSC5 antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7002295 at dilution 1:100
anti-EXOSC5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-EXOSC5 antibody    Immunohistochemistry of paraffin-embedded human breast cancer tissue using MBS7002295 at dilution 1:100
anti-EXOSC5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for EXOSC5. It may not necessarily be applicable to this product.
 NCBI GI #    47174864
 NCBI GeneID    56915
 NCBI Accession #    NP_064543.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_020158.3 [Other Products]
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 UniProt Primary Accession #    Q9NQT4 [Other Products]
 UniProt Secondary Accession #    Q32Q81; Q8NG16; Q96I89 [Other Products]
 UniProt Related Accession #    Q9NQT4 [Other Products]
 Molecular Weight    25,249 Da
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 NCBI Official Full Name    exosome complex component RRP46
 NCBI Official Synonym Full Names    exosome component 5
 NCBI Official Symbol    EXOSC5 [Similar Products]
 NCBI Official Synonym Symbols   
p12B; RRP46; RRP41B; Rrp46p; hRrp46p
[Similar Products]
 NCBI Protein Information    exosome complex component RRP46
 UniProt Protein Name    Exosome complex component RRP46
 UniProt Synonym Protein Names   
Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B
 Protein Family    Exosome complex component
 UniProt Gene Name    EXOSC5 [Similar Products]
 UniProt Synonym Gene Names    CML28; RRP46 [Similar Products]
 UniProt Entry Name    EXOS5_HUMAN
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 UniProt Comments for EXOSC5    EXOSC5: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family.

Protein type: EC 3.1.13.-; Nucleolus; Ribonuclease

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nucleolus; nucleus

Molecular Function: 3'-5'-exoribonuclease activity; exoribonuclease activity; protein binding; RNA binding

Biological Process: defense response to virus; DNA deamination; gene expression; mRNA catabolic process, deadenylation-dependent decay; regulation of mRNA stability; rRNA 3'-end processing; rRNA catabolic process; rRNA processing
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 Research Articles on EXOSC5    1. Further, subcellular co-localization assay showed that the two proteins could co-localize in the cytoplasm of K562 cells, but WT1/CML28 complexes were not detected by using immunoprecipitation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EXOSC5 antibodyPathways associated with anti-EXOSC5 antibody
 Reference Product  PubMed Publications
 EXOSC4 antibody  >1 publications with EXOSC5 and EXOSC4
 Products by Pathway  Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 Butyrate Response Factor 1 (BRF1) Binds And Destabilizes MRNA Pathway antibodies  Butyrate Response Factor 1 (BRF1) Binds And Destabilizes MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Exosome, Eukaryotes Pathway antibodies  Exosome, Eukaryotes Pathway Diagram
 Exosome, Eukaryotes Pathway antibodies  Exosome, Eukaryotes Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 KSRP (KHSRP) Binds And Destabilizes MRNA Pathway antibodies  KSRP (KHSRP) Binds And Destabilizes MRNA Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 PERK Regulates Gene Expression Pathway antibodies  PERK Regulates Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
Organs/Tissues associated with anti-EXOSC5 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with EXOSC5 and Blood
 Testis Antibodies  >3 publications with EXOSC5 and Testis
 Bone Antibodies  >1 publications with EXOSC5 and Bone
 Prostate Antibodies  >1 publications with EXOSC5 and Prostate
 Bone Marrow Antibodies  >1 publications with EXOSC5 and Bone Marrow
 Lung Antibodies  >1 publications with EXOSC5 and Lung
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