NP_000118.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,255 Da
NCBI Official Full Name
exostosin-1
NCBI Official Synonym Full Names
exostosin glycosyltransferase 1
NCBI Protein Information
exostosin-1
UniProt Protein Name
Exostosin-1
UniProt Synonym Protein Names
Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostoses protein 1; Putative tumor suppressor protein EXT1
NCBI Summary for EXT1
This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq, Jul 2008]
UniProt Comments for EXT1
Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Product References and Citations for anti-EXT1 antibody
(1) Ciavarella, M., Coco, M., Baorda, F., et al. 20 novel point mutations and one large deletion in EXT1 and EXT2 genes: report of diagnostic screening in a large Italian cohort of patients affected by hereditary multiple exostosis. Gene 515 (2), 339-348 (2013).
Research Articles on EXT1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-EXT1 antibody
Pathways associated with anti-EXT1 antibody
Diseases associated with anti-EXT1 antibody
Disease Name |
Pubmed Publications |
EXOSTOSES, MULTIPLE, TYPE I Antibodies |
>194 publications with EXT1 and EXOSTOSES, MULTIPLE, TYPE I |
Exostoses, Multiple Hereditary Antibodies |
>194 publications with EXT1 and Exostoses, Multiple Hereditary |
Chondrosarcoma Antibodies |
>40 publications with EXT1 and Chondrosarcoma |
Nervous System Diseases Antibodies |
>14 publications with EXT1 and Nervous System Diseases |
Disease Models, Animal Antibodies |
>13 publications with EXT1 and Disease Models, Animal |
Breast Neoplasms Antibodies |
>8 publications with EXT1 and Breast Neoplasms |
Cell Transformation, Neoplastic Antibodies |
>7 publications with EXT1 and Cell Transformation, Neoplastic |
Adenocarcinoma Antibodies |
>5 publications with EXT1 and Adenocarcinoma |
Liver Diseases Antibodies |
>5 publications with EXT1 and Liver Diseases |
Necrosis Antibodies |
>4 publications with EXT1 and Necrosis |
Organs/Tissues associated with anti-EXT1 antibody
|