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anti-EXT2 antibody :: Rabbit EXT2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524268
Testing Data
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EXT2, Polyclonal Antibody

★Popular Item★
 Also Known As   

EXT2 Antibody

 Product Synonym Names    SOTV
 Product Gene Name   

anti-EXT2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    133701
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of EXT2
 Calculated Molecular Weight: 718aa; 82kd
Observed Molecular Weight: 70-82kd
  
 Buffer    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-11045 / sc-11042
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EXT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EXT2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-EXT2 antibody    WB: 1:500-1:5000
IHC: 1:20-1:200
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 Testing Data of anti-EXT2 antibody    anti-EXT2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for EXT2. It may not necessarily be applicable to this product.
 NCBI GI #    296010875
 NCBI GeneID    2132
 NCBI Accession #    NP_001171554.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001178083.1 [Other Products]
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 UniProt Secondary Accession #    O15288; B2R5Z6; C9JU51; J3KPT2 [Other Products]
 UniProt Related Accession #    Q93063 [Other Products]
 Molecular Weight    85,815 Da
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 NCBI Official Full Name    exostosin-2 isoform 3
 NCBI Official Synonym Full Names    exostosin glycosyltransferase 2
 NCBI Official Symbol    EXT2 [Similar Products]
 NCBI Official Synonym Symbols   
SOTV
[Similar Products]
 NCBI Protein Information    exostosin-2; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; multiple exostoses protein 2; putative tumor suppressor protein EXT2
 UniProt Protein Name    Exostosin-2
 UniProt Synonym Protein Names   
Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostoses protein 2; Putative tumor suppressor protein EXT2
 Protein Family    Extensin
 UniProt Gene Name    EXT2 [Similar Products]
 UniProt Entry Name    EXT2_HUMAN
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 NCBI Summary for EXT2    This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EXT2    EXT2: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Defects in EXT2 are a cause of hereditary multiple exostoses type 2 (EXT2). EXT is a genetically heterogeneous bone disorder caused by genes segregating on human chromosomes 8, 11, and 19 and designated EXT1, EXT2 and EXT3 respectively. EXT is a dominantly inherited skeletal disorder primarily affecting endochondral bone during growth. The disease is characterized by formation of numerous cartilage-capped, benign bone tumors (osteocartilaginous exostoses or osteochondromas) that are often accompanied by skeletal deformities and short stature. In a small percentage of cases exostoses have exhibited malignant transformation resulting in an osteosarcoma or chondrosarcoma. Osteochondromas development can also occur as a sporadic event. Defects in EXT2 are a cause of Potocki-Shaffer syndrome (POSHS). It is a contiguous gene syndrome due to proximal deletion of chromosome 11p11.2, including EXT2 and ALX4. Belongs to the glycosyltransferase 47 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Glycan Metabolism - heparan sulfate biosynthesis; EC 2.4.1.225; Tumor suppressor; EC 2.4.1.224; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p12-p11

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: acetylglucosaminyltransferase activity; transferase activity, transferring glycosyl groups; protein homodimerization activity; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; protein heterodimerization activity; glucuronosyltransferase activity; heparan sulfate N-acetylglucosaminyltransferase activity; metal ion binding; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

Biological Process: glycosaminoglycan biosynthetic process; ossification; cellular polysaccharide biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; mesoderm formation; glycosaminoglycan metabolic process; heparan sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; protein amino acid glycosylation; pathogenesis; cell differentiation; signal transduction

Disease: Exostoses, Multiple, Type Ii
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 Research Articles on EXT2    1. This study demonstrated no association of rs1113132, rs3740878 and rs11037909 EXT2 variants with type 2 diabetes mellitus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EXT2 antibodyPathways associated with anti-EXT2 antibody
 Reference Product  PubMed Publications
 EXT1 antibody  >184 publications with EXT2 and EXT1
 NDST1 antibody  >3 publications with EXT2 and NDST1
 NDST2 antibody  >2 publications with EXT2 and NDST2
 GPC3 antibody  >1 publications with EXT2 and GPC3
 SDC2 antibody  >1 publications with EXT2 and SDC2
 Products by Pathway  Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Defective EXT2 Causes Exostoses 2 Pathway antibodies  Defective EXT2 Causes Exostoses 2 Pathway Diagram
 Defective PAPSS2 Causes SEMD-PA Pathway antibodies  Defective PAPSS2 Causes SEMD-PA Pathway Diagram
Diseases associated with anti-EXT2 antibodyOrgans/Tissues associated with anti-EXT2 antibody
 Disease Name  Pubmed Publications
 Exostoses, Multiple Hereditary Antibodies  >159 publications with EXT2 and Exostoses, Multiple Hereditary
 Congenital Abnormalities Antibodies  >10 publications with EXT2 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >9 publications with EXT2 and Disease Models, Animal
 Nervous System Diseases Antibodies  >9 publications with EXT2 and Nervous System Diseases
 Kidney Diseases Antibodies  >4 publications with EXT2 and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with EXT2 and Cell Transformation, Neoplastic
 EXOSTOSES, MULTIPLE, TYPE II Antibodies  >3 publications with EXT2 and EXOSTOSES, MULTIPLE, TYPE II
 Hypertrophy Antibodies  >2 publications with EXT2 and Hypertrophy
 Liver Failure Antibodies  >2 publications with EXT2 and Liver Failure
 Liver Diseases Antibodies  >2 publications with EXT2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >99 publications with EXT2 and Bone
 Connective Tissue Antibodies  >13 publications with EXT2 and Connective Tissue
 Blood Antibodies  >12 publications with EXT2 and Blood
 Brain Antibodies  >8 publications with EXT2 and Brain
 Muscle Antibodies  >6 publications with EXT2 and Muscle
 Vascular Antibodies  >5 publications with EXT2 and Vascular
 Kidney Antibodies  >5 publications with EXT2 and Kidney
 Pancreas Antibodies  >4 publications with EXT2 and Pancreas
 Embryonic Tissue Antibodies  >4 publications with EXT2 and Embryonic Tissue
 Nerve Antibodies  >4 publications with EXT2 and Nerve
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