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anti-ENPP1 antibody :: anti-Human Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2017629 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-ENPP1 antibody
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1), Polyclonal Antibody

 Also Known As   

FITC-linked Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1)

 Product Gene Name   

anti-ENPP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (132129156..132216295). Location: 6q22-q23
 OMIM    125853
 3D Structure    ModBase 3D Structure for P22413
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 Clonality    Polyclonal
 Species Reactivity    Human
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 Concentration    200ug/ml (lot specific)
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-ENPP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ENPP1 antibody    FITC Antibody
 Applications Tested/Suitable for anti-ENPP1 antibody   

Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ENPP1. It may not necessarily be applicable to this product.
 NCBI GI #    133777224
 NCBI GeneID    5167
 NCBI Accession #    AAH59375.2 [Other Products]
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 UniProt Primary Accession #    P22413 [Other Products]
 UniProt Secondary Accession #    Q5T9R6; Q9NPZ3; Q9P1P6; Q9UP61; Q9Y6K3 [Other Products]
 UniProt Related Accession #    P22413 [Other Products]
 Molecular Weight    104,924 Da
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 NCBI Official Full Name    Ectonucleotide pyrophosphatase/phosphodiesterase 1
 NCBI Official Synonym Full Names    ectonucleotide pyrophosphatase/phosphodiesterase 1
 NCBI Official Symbol    ENPP1 [Similar Products]
 NCBI Official Synonym Symbols   
M6S1; NPP1; NPPS; PC-1; PCA1; ARHR2; COLED; PDNP1
[Similar Products]
 NCBI Protein Information    ectonucleotide pyrophosphatase/phosphodiesterase family member 1; E-NPP 1; Ly-41 antigen; alkaline phosphodiesterase 1; plasma-cell membrane glycoprotein 1; plasma-cell membrane glycoprotein PC-1; membrane component chromosome 6 surface marker 1; phosphodiesterase I/nucleotide pyrophosphatase 1; membrane component, chromosome 6, surface marker 1
 UniProt Protein Name    Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
 UniProt Synonym Protein Names   
Membrane component chromosome 6 surface marker 1; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1
 Protein Family    Ectonucleotide pyrophosphatase/phosphodiesterase family
 UniProt Gene Name    ENPP1 [Similar Products]
 UniProt Synonym Gene Names    M6S1; NPPS; PC1; PDNP1; E-NPP 1; NPPase [Similar Products]
 UniProt Entry Name    ENPP1_HUMAN
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 NCBI Summary for ENPP1    This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ENPP1    ENPP1: Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity. Homodimer; disulfide-linked. Interacts with INSR. Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis. At low concentrations of ATP, a phosphorylated intermediate is formed which inhibits further hydrolysis. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Protein type: EC 3.1.4.1; Carbohydrate Metabolism - starch and sucrose; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - riboflavin; Nucleotide Metabolism - purine; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Motility/polarity/chemotaxis; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Membrane protein, integral; Phosphodiesterase; EC 3.6.1.9

Chromosomal Location of Human Ortholog: 6q22-q23

Cellular Component: extracellular space; cell surface; integral to plasma membrane; lysosomal membrane; basolateral plasma membrane; plasma membrane; integral to membrane

Molecular Function: phosphodiesterase I activity; nucleotide diphosphatase activity; protein homodimerization activity; 3'-phosphoadenosine 5'-phosphosulfate binding; zinc ion binding; calcium ion binding; nucleoside-triphosphate diphosphatase activity; insulin receptor binding; polysaccharide binding; protein binding; nucleic acid binding; ATP binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; generation of precursor metabolites and energy; sequestering of triacylglycerol; vitamin metabolic process; nucleoside triphosphate catabolic process; negative regulation of insulin receptor signaling pathway; bone remodeling; negative regulation of fat cell differentiation; phosphate metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; riboflavin metabolic process; negative regulation of glucose import; cellular phosphate ion homeostasis; cellular response to insulin stimulus; biomineral formation; negative regulation of ossification; negative regulation of protein amino acid autophosphorylation; immune response; negative regulation of cell growth; regulation of bone mineralization; water-soluble vitamin metabolic process; inorganic diphosphate transport; negative regulation of glycogen biosynthetic process

Disease: Obesity; Cole Disease; Arterial Calcification, Generalized, Of Infancy, 1; Hypophosphatemic Rickets, Autosomal Recessive, 2; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on ENPP1    1. Platelets and serum E-NPP1 activity increased in prostate cancer patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ENPP1 antibodyPathways associated with anti-ENPP1 antibody
 Reference Product  PubMed Publications
 NT5E antibody  >4 publications with ENPP1 and NT5E
 CD38 antibody  >1 publications with ENPP1 and CD38
 Products by Pathway  Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
 Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies  Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
 Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies  Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram
Diseases associated with anti-ENPP1 antibodyOrgans/Tissues associated with anti-ENPP1 antibody
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >60 publications with ENPP1 and Diabetes Mellitus, Type 2
 Obesity Antibodies  >49 publications with ENPP1 and Obesity
 Arterial calcification of infancy Antibodies  >25 publications with ENPP1 and Arterial calcification of infancy
 Kidney Diseases Antibodies  >18 publications with ENPP1 and Kidney Diseases
 Disease Models, Animal Antibodies  >8 publications with ENPP1 and Disease Models, Animal
 Liver Diseases Antibodies  >8 publications with ENPP1 and Liver Diseases
 Hyperglycemia Antibodies  >7 publications with ENPP1 and Hyperglycemia
 Inflammation Antibodies  >6 publications with ENPP1 and Inflammation
 Fatty Liver Antibodies  >4 publications with ENPP1 and Fatty Liver
 Hypophosphatemic Rickets, Autosomal Recessive, 2 Antibodies  >4 publications with ENPP1 and Hypophosphatemic Rickets, Autosomal Recessive, 2
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >47 publications with ENPP1 and Bone
 Blood Antibodies  >42 publications with ENPP1 and Blood
 Heart Antibodies  >21 publications with ENPP1 and Heart
 Muscle Antibodies  >16 publications with ENPP1 and Muscle
 Connective Tissue Antibodies  >15 publications with ENPP1 and Connective Tissue
 Liver Antibodies  >14 publications with ENPP1 and Liver
 Kidney Antibodies  >13 publications with ENPP1 and Kidney
 Skin Antibodies  >9 publications with ENPP1 and Skin
 Embryonic Tissue Antibodies  >5 publications with ENPP1 and Embryonic Tissue
 Eye Antibodies  >3 publications with ENPP1 and Eye
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