Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow ELN rightarrow Polyclonal ELN  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Inter Alpha-Globulin Inhibitor H3 (ITIH3) ELISA Kit
 • SIAH1 Antibody
 • Chick Fibroblast Basal Medium MCDB 201 Culture Media
 • wingless-type MMTV integration site family, member 10B (WNT1... ELISA Kit
 • Encephalitis, Japanese Recombinant Protein
 • LIM domain kinase 1 (LIMK1) ELISA Kit
 • alpha2-Macroglobulin (alpha2-MG) ELISA Kit
 • CCR2 Antibody
 • Cholecystokinin (CCK) ELISA Kit
 • Total Carbohydrate Assay Kit
 • Thrombospondin 1 (TSP-1 ) ELISA Kit
 • 2,3-bisphosphoglycerate-dep endent phosphoglycerate mutase (g... Recombinant Protein
 • H-2 class II histocompatibility antigen, A beta chain (H2-Ab... Recombinant Protein
 • RACGAP1 - MgcRacGAP Peptide
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-ELN antibody :: Rabbit anti-Human Elastin, Aortic Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS623261 anti-ELN antibody
Unit / Price
0.5 mL  /  $810 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Elastin, Aortic (ELN), Polyclonal Antibody

 Also Known As   

Elastin, Aortic

 Product Synonym Names    Anti -Elastin, Aortic
 Product Gene Name   

anti-ELN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 7; NC_000007.13 (73442119..73484237). Location: 7q11.23
 OMIM    123700
 3D Structure    ModBase 3D Structure for P15502
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Specificity    Recognizes human insoluble elastin and human tropoelastin. Low Species Crossreactivity: bovine, rabbit, canine. This antibody shows little if any reactivity with rat elastin.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a lyophilized powder. Reconstitute with sterile 40-50% glycerol, dH2O, 0.01% Thimerosal.
Section Bar
 Immunogen    Insoluble elastin purified from human aorta by hot sodium hydroxide.
Section Bar
 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute by adding sterile 40-50% glycerol, ddH2O. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ELN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-ELN antibody

   Elastin is a protein in connective tissue that is elastic and allows many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing tissue in the bodies of mammals and used in places where mechanical energy is required to be stored. Elastin is particularly abundant in large elastic blood vessels such as the aorta. It is also very important in the lungs, elastic ligaments, the skin, the bladder, and elastic cartilage.
 Product Categories/Family for anti-ELN antibody    Antibodies; Abs to Elastin
 Applications Tested/Suitable for anti-ELN antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

 Application Notes for anti-ELN antibody    Suitable for Western Blot, ELISA, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.
Dilution: ELISA: 1:1000 -1:2000
Western Blot: 1:200 -1:500
Immunoprecipitation: 1:100 -1:200
Immunohistochemistry: 1:50 -1:100
In many cases, antigenicity of elastic fiber components can be enhanced by treating with 6M guanidine HCl, 50mM dithiothreitol, 20mM Tris pH 8.0 for 15 minutes. After washing with 20mM Tris pH 8.0, the slides are treated with 100mM iodoacetamide in the dark for 15 minutes, washed and stained using normal protocols.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ELN. It may not necessarily be applicable to this product.
 NCBI GI #    525313599
 NCBI GeneID    2006
 NCBI Accession #    NP_001265868.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278939.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P15502 [Other Products]
 UniProt Secondary Accession #    O15336; O15337; Q14233; Q14234; Q14235; Q14238; Q6P0L4; Q6ZWJ6; Q75MU5; Q7Z316; B3KTS6 [Other Products]
 UniProt Related Accession #    P15502 [Other Products]
 Molecular Weight    68,469 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    elastin isoform m
 NCBI Official Synonym Full Names    elastin
 NCBI Official Symbol    ELN [Similar Products]
 NCBI Official Synonym Symbols   
WS; WBS; SVAS
[Similar Products]
 NCBI Protein Information    elastin; tropoelastin
 UniProt Protein Name    Elastin
 UniProt Synonym Protein Names   
Tropoelastin
 Protein Family    Elastin
 UniProt Gene Name    ELN [Similar Products]
 UniProt Entry Name    ELN_HUMAN
Section Bar
 NCBI Summary for ELN    This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for ELN    elastin: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Defects in ELN are the cause of cutis laxa, autosomal dominant, type 1 (ADCL1). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Defects in ELN are the cause of supravalvular aortic stenosis (SVAS). SVAS is a congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome. ELN is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. Belongs to the elastin family. 13 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Extracellular matrix; Secreted

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: protein binding; extracellular matrix structural constituent

Biological Process: extracellular matrix disassembly; cell proliferation; organ morphogenesis; extracellular matrix organization and biogenesis; blood circulation; respiratory gaseous exchange

Disease: Cutis Laxa, Autosomal Dominant 1; Williams-beuren Syndrome; Supravalvular Aortic Stenosis
Table BarTOPTable Bar
 Research Articles on ELN    1. we provide an overview of the major cytokines/growth factors that modulate elastogenesis and describe the underlying molecular mechanisms for their action on elastin production.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-ELN antibodyDiseases associated with anti-ELN antibody
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >87 publications with ELN and Heart Diseases
 Aortic Stenosis, Supravalvular Antibodies  >67 publications with ELN and Aortic Stenosis, Supravalvular
 Nervous System Diseases Antibodies  >62 publications with ELN and Nervous System Diseases
 Williams Syndrome Antibodies  >60 publications with ELN and Williams Syndrome
 Neoplasms Antibodies  >39 publications with ELN and Neoplasms
 Hypertension Antibodies  >18 publications with ELN and Hypertension
 Disease Models, Animal Antibodies  >16 publications with ELN and Disease Models, Animal
 Cutis Laxa Antibodies  >10 publications with ELN and Cutis Laxa
 Heart Defects, Congenital Antibodies  >10 publications with ELN and Heart Defects, Congenital
 Hypertrophy Antibodies  >8 publications with ELN and Hypertrophy
Organs/Tissues associated with anti-ELN antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >55 publications with ELN and Vascular
 Muscle Antibodies  >43 publications with ELN and Muscle
 Heart Antibodies  >39 publications with ELN and Heart
 Lung Antibodies  >22 publications with ELN and Lung
 Brain Antibodies  >22 publications with ELN and Brain
 Connective Tissue Antibodies  >22 publications with ELN and Connective Tissue
 Skin Antibodies  >19 publications with ELN and Skin
 Bone Antibodies  >14 publications with ELN and Bone
 Intestine Antibodies  >13 publications with ELN and Intestine
 Eye Antibodies  >9 publications with ELN and Eye
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions