NP_001107595.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
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NCBI Official Full Name
ETS domain-containing protein Elk-1
NCBI Official Synonym Full Names
ELK1, member of ETS oncogene family
NCBI Protein Information
ETS domain-containing protein Elk-1; ETS-like gene 1; OTTHUMP00000023224; OTTHUMP00000023225
UniProt Protein Name
ETS domain-containing protein Elk-1
UniProt Entry Name
ELK1_HUMAN
NCBI Summary for ELK1
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
UniProt Comments for ELK1
ELK1: a transcription factor of the Ets family and the ternary complex factor (TCF) subfamily. Forms a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. Mediates gene activity in response to serum and growth factors. Phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus; phosphorylation at these sites is critical for transcriptional activation by Elk-1. Two alternatively-spliced isoforms have been described.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: Xp11.2
Cellular Component: nucleoplasm; mitochondrion; cell soma; dendrite; nerve terminal; nucleus
Molecular Function: protein binding; double-stranded DNA binding; chromatin binding; transcription factor activity
Biological Process: toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; transcription from RNA polymerase II promoter; response to light stimulus; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; toll-like receptor 3 signaling pathway; cell differentiation; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway
Research Articles on ELK1
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Products associated with anti-ELK1 antibody
Pathways associated with anti-ELK1 antibody
Diseases associated with anti-ELK1 antibody
Organs/Tissues associated with anti-ELK1 antibody
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