NP_003016.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,519 Da
NCBI Official Full Name
endophilin-A2 isoform 1
NCBI Official Synonym Full Names
SH3 domain containing GRB2 like 1, endophilin A2
NCBI Protein Information
endophilin-A2
UniProt Protein Name
Endophilin-A2
UniProt Synonym Protein Names
EEN fusion partner of MLL; Endophilin-2; Extra eleven-nineteen leukemia fusion gene protein; EEN; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1
UniProt Synonym Gene Names
UniProt Entry Name
SH3G1_HUMAN
NCBI Summary for SH3GL1
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for SH3GL1
SH3GL1: Implicated in endocytosis. May recruit other proteins to membranes with high curvature. In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene. Belongs to the endophilin family.
Protein type: Vesicle; Oncoprotein
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cell junction; cell projection; cytoplasm; early endosome membrane; podosome
Molecular Function: GTPase binding; identical protein binding; lipid binding; phosphatase binding; protein binding
Biological Process: central nervous system development; endocytosis; signal transduction
Disease: Leukemia, Acute Myeloid
Research Articles on SH3GL1
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Products associated with anti-SH3GL1 antibody
Pathways associated with anti-SH3GL1 antibody
Diseases associated with anti-SH3GL1 antibody
Organs/Tissues associated with anti-SH3GL1 antibody
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