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anti-PROCR antibody :: Rabbit anti-Human Endothelial protein C receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1265009 anti-PROCR antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Endothelial protein C receptor (PROCR), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Endothelial protein C receptor polyclonal Antibody, Biotin conjugated

 Product Synonym Names    Activated protein C receptor; Endothelial cell protein C receptor; CD_antigen=CD201; PROCR; EPCR
 Product Gene Name   

anti-PROCR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600646
 3D Structure    ModBase 3D Structure for Q9UNN8
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Biotin
 Immunogen    Recombinant human Endothelial protein C receptor protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23575 / sc-31264 / sc-31265 / sc-28978
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PROCR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PROCR antibody

   Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
 Applications Tested/Suitable for anti-PROCR antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for PROCR. It may not necessarily be applicable to this product.
 NCBI GI #    34335272
 NCBI GeneID    10544
 NCBI Accession #    NP_006395.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006404.4 [Other Products]
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 UniProt Primary Accession #    Q9UNN8 [Other Products]
 UniProt Secondary Accession #    Q14218; Q6IB56; Q96CB3; Q9ULX1; B2RC04 [Other Products]
 UniProt Related Accession #    Q9UNN8 [Other Products]
 Molecular Weight    26,671 Da [Similar Products]
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 NCBI Official Full Name    endothelial protein C receptor
 NCBI Official Synonym Full Names    protein C receptor
 NCBI Official Symbol    PROCR [Similar Products]
 NCBI Official Synonym Symbols   
CCCA; EPCR; CCD41
[Similar Products]
 NCBI Protein Information    endothelial protein C receptor
 UniProt Protein Name    Endothelial protein C receptor
 UniProt Synonym Protein Names   
Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD_antigen: CD201
 Protein Family    Endothelial protein C receptor
 UniProt Gene Name    PROCR [Similar Products]
 UniProt Synonym Gene Names    EPCR; APC receptor [Similar Products]
 UniProt Entry Name    EPCR_HUMAN
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 NCBI Summary for PROCR    The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
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 UniProt Comments for PROCR    EPCR: a single-pass type I membrane protein. Binds activated protein C (APC), a serine protease that regulates thrombin (IIa) production. Plays a pivotal role in preventing blood coagulation through binding of activated protein C. Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. The binding of APC to EPCR and PAR-1 increases invasion and chemotaxis.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: cell surface; centrosome; extracellular region; focal adhesion; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: blood coagulation; immune response; leukocyte migration; negative regulation of coagulation
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 Research Articles on PROCR    1. results did not conclusively identify a direct role of sEPCR in HSP, but our findings warrant further investigations, especially in severe HSP cases characterized by gastrointestinal bleeding or renal involvement
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PROCR antibodyPathways associated with anti-PROCR antibody
 Reference Product  PubMed Publications
 APC antibody  >87 publications with PROCR and APC
 THBD antibody  >10 publications with PROCR and THBD
 PROC antibody  >10 publications with PROCR and PROC
 CAV1 antibody  >3 publications with PROCR and CAV1
 F2R antibody  >2 publications with PROCR and F2R
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Common Pathway Of Fibrin Clot Formation antibodies  Common Pathway Of Fibrin Clot Formation Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-PROCR antibodyOrgans/Tissues associated with anti-PROCR antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >92 publications with PROCR and Inflammation
 Cardiovascular Diseases Antibodies  >80 publications with PROCR and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >30 publications with PROCR and Nervous System Diseases
 Disease Models, Animal Antibodies  >18 publications with PROCR and Disease Models, Animal
 Lung Diseases Antibodies  >16 publications with PROCR and Lung Diseases
 Heart Diseases Antibodies  >13 publications with PROCR and Heart Diseases
 Breast Neoplasms Antibodies  >12 publications with PROCR and Breast Neoplasms
 Kidney Diseases Antibodies  >10 publications with PROCR and Kidney Diseases
 Carcinoma Antibodies  >9 publications with PROCR and Carcinoma
 Lung Injury Antibodies  >9 publications with PROCR and Lung Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >182 publications with PROCR and Blood
 Vascular Antibodies  >124 publications with PROCR and Vascular
 Lung Antibodies  >23 publications with PROCR and Lung
 Brain Antibodies  >16 publications with PROCR and Brain
 Bone Antibodies  >15 publications with PROCR and Bone
 Heart Antibodies  >13 publications with PROCR and Heart
 Kidney Antibodies  >12 publications with PROCR and Kidney
 Liver Antibodies  >11 publications with PROCR and Liver
 Embryonic Tissue Antibodies  >10 publications with PROCR and Embryonic Tissue
 Muscle Antibodies  >10 publications with PROCR and Muscle
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