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anti-EGFR antibody :: Rabbit anti-Human Epidermal Growth Factor Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS621694 anti-EGFR antibody
Unit / Price
0.1 mL  /  $610 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Epidermal Growth Factor Receptor (EGFR), Polyclonal Antibody

 Also Known As   

Epidermal Growth Factor Receptor, phosphorylated (Tyr845) (EGFR)

 Product Synonym Names    Anti -Epidermal Growth Factor Receptor, phosphorylated (Tyr845) (EGFR)
 Product Gene Name   

anti-EGFR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (55086725..55275031). Location: 7p12
 OMIM    131550
 3D Structure    ModBase 3D Structure for P00533
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes phospho-EGFR (Tyr845), Mr 185kD.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography
 Form/Format    Supplied as a liquid PBS, pH 7.3 containing 1mg/mL BSA, 0.05% sodium azide and 50% glycerol.
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 Immunogen    Synthetic phosphopeptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-EGFR (Tyr845).
 Species Sequence Homology    Mouse and rat
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-EGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-EGFR antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-EGFR antibody   

Western Blot (WB)

 Application Notes for anti-EGFR antibody    Suitabe for use in Western Blot.
Dilution: Western Blot: 1:1000
Optimal dilution to be determined by researcher.
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NCBI/Uniprot data below describe general gene information for EGFR. It may not necessarily be applicable to this product.
 NCBI GI #    2811086
 NCBI GeneID    1956
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 UniProt Primary Accession #    P00533 [Other Products]
 UniProt Secondary Accession #    O00688; O00732; P06268; Q14225; Q68GS5; Q92795; Q9BZS2; Q9GZX1; Q9H2C9; Q9H3C9; Q9UMD7 [Other Products]
 UniProt Related Accession #    P00533; Q147T7; Q2TTR7; Q504U8; Q59FL8; Q68GS6; Q75MF2; Q8WZA5; Q9H3C8 [Other Products]
 Molecular Weight    134,277 Da [Similar Products]
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 NCBI Official Full Name    Epidermal growth factor receptor
 NCBI Official Synonym Full Names    epidermal growth factor receptor
 NCBI Official Symbol    EGFR [Similar Products]
 NCBI Official Synonym Symbols   
ERBB; HER1; mENA; ERBB1; PIG61
[Similar Products]
 NCBI Protein Information    epidermal growth factor receptor; OTTHUMP00000159661; OTTHUMP00000159662; OTTHUMP00000159663; OTTHUMP00000209210; OTTHUMP00000209211; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
 UniProt Protein Name    Epidermal growth factor receptor
 UniProt Synonym Protein Names   
Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
 Protein Family    Epidermal growth factor receptor
 UniProt Gene Name    EGFR [Similar Products]
 UniProt Synonym Gene Names    ERBB1 [Similar Products]
 UniProt Entry Name    EGFR_HUMAN
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 NCBI Summary for EGFR    The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for EGFR    EGFR: a receptor tyrosine kinase. This is a receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30, and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentiation. It is a single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation. It can be phosphorylated and activated by Src. Activated EGFR binds the SH2 domain of phospholipase C-gamma (PLC-gamma), activating PLC-gamma-mediated downstream signaling. Phosphorylated EGFR binds Cbl, leading to its ubiquitination and degradation. Grb2 and SHC bind to phospho-EGFR and are involved in the activation of MAP kinase signaling pathways. Phosphorylation on Ser and Thr residues is thought to represent a mechanism for attenuation of EGFR kinase activity. EGFR is overexpressed in breast, head and neck cancers, correlating with poor survival. Activating somatic mutations are seen in lung cancer, corresponding to the minority of patients with strong responses to the EGFR inhibitor Iressa (gefitinib). Mutations and amplifications are also seen in glioblastoma, and upregulation is seen in colon cancer and neoplasms. In xenografts, inhibitors synergize with cytotoxic drugs in the inhibition of many tumor types. Inhibitors include: Iressa/ZD1839, Erbitux, Tarceva, and lapatinib. Four alternatively spliced isoforms have been described.

Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; Tumor suppressor; EC 2.7.10.1; Membrane protein, integral; TK group; EGFR family

Chromosomal Location of Human Ortholog: 7p12

Cellular Component: extracellular space; endoplasmic reticulum membrane; nuclear membrane; cell surface; focal adhesion; basolateral plasma membrane; integral to membrane; lipid raft; Golgi membrane; membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; plasma membrane; AP-2 adaptor complex; endosome membrane; nucleus; receptor complex; endosome

Molecular Function: identical protein binding; epidermal growth factor receptor activity; epidermal growth factor binding; nitric-oxide synthase regulator activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; protein kinase binding; actin filament binding; integrin binding; protein binding; enzyme binding; transmembrane receptor activity; MAP kinase kinase kinase activity; protein heterodimerization activity; protein-tyrosine kinase activity; ubiquitin protein ligase binding; double-stranded DNA binding; chromatin binding; glycoprotein binding; ATP binding

Biological Process: circadian rhythm; diterpenoid metabolic process; positive regulation of nitric oxide biosynthetic process; nerve growth factor receptor signaling pathway; activation of MAPKK activity; alkanesulfonate metabolic process; positive regulation of vasodilation; protein insertion into membrane; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of MAP kinase activity; positive regulation of fibroblast proliferation; cell-cell adhesion; cell surface receptor linked signal transduction; ovulation cycle; hair follicle development; positive regulation of superoxide release; negative regulation of mitotic cell cycle; positive regulation of DNA repair; fibroblast growth factor receptor signaling pathway; digestive tract morphogenesis; response to osmotic stress; phospholipase C activation; hydrogen peroxide metabolic process; response to hydroxyisoflavone; positive regulation of transcription from RNA polymerase II promoter; response to oxidative stress; regulation of nitric-oxide synthase activity; negative regulation of protein catabolic process; response to calcium ion; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of epidermal growth factor receptor signaling pathway; tongue development; axon guidance; embryonic placenta development; peptidyl-tyrosine phosphorylation; translation; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; signal transduction; positive regulation of synaptic transmission, glutamatergic; learning and/or memory; salivary gland morphogenesis; positive regulation of cell proliferation; response to stress; regulation of peptidyl-tyrosine phosphorylation; epidermal growth factor receptor signaling pathway; ossification; phosphoinositide-mediated signaling; MAPKKK cascade; liver development; positive regulation of protein kinase B signaling cascade; cell proliferation; cerebral cortex cell migration; calcium-dependent phospholipase A2 activation; positive regulation of vasoconstriction; innate immune response; positive regulation of protein amino acid phosphorylation; astrocyte activation; response to cobalamin; positive regulation of phosphorylation; positive regulation of DNA replication; lung development; positive regulation of inflammatory response; positive regulation of cell migration

Disease: Lung Cancer
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 Research Articles on EGFR    1. EGFR was found to be expressed in 61.8% of brain gliomas, with strongly positive expression in 12.2% of them
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EGFR antibodyPathways associated with anti-EGFR antibody
 Reference Product  PubMed Publications
 EGF antibody  >4510 publications with EGFR and EGF
 ERBB2 antibody  >2276 publications with EGFR and ERBB2
 MET antibody  >534 publications with EGFR and MET
 MAPK1 antibody  >398 publications with EGFR and MAPK1
 ERBB3 antibody  >306 publications with EGFR and ERBB3
 STAT3 antibody  >299 publications with EGFR and STAT3
 CTNNB1 antibody  >232 publications with EGFR and CTNNB1
 GRB2 antibody  >216 publications with EGFR and GRB2
 ERBB4 antibody  >211 publications with EGFR and ERBB4
 CBL antibody  >203 publications with EGFR and CBL
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with anti-EGFR antibodyOrgans/Tissues associated with anti-EGFR antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9975 publications with EGFR and Neoplasms
 Carcinoma Antibodies  >5441 publications with EGFR and Carcinoma
 Lung Neoplasms Antibodies  >2652 publications with EGFR and Lung Neoplasms
 Lung Diseases Antibodies  >2485 publications with EGFR and Lung Diseases
 Adenocarcinoma Antibodies  >2073 publications with EGFR and Adenocarcinoma
 Breast Neoplasms Antibodies  >1765 publications with EGFR and Breast Neoplasms
 Carcinoma, Non-Small-Cell Lung Antibodies  >1763 publications with EGFR and Carcinoma, Non-Small-Cell Lung
 Kidney Diseases Antibodies  >1550 publications with EGFR and Kidney Diseases
 Carcinoma, Squamous Cell Antibodies  >1512 publications with EGFR and Carcinoma, Squamous Cell
 Head and Neck Neoplasms Antibodies  >1305 publications with EGFR and Head and Neck Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3470 publications with EGFR and Lung
 Kidney Antibodies  >2186 publications with EGFR and Kidney
 Vascular Antibodies  >1437 publications with EGFR and Vascular
 Brain Antibodies  >1203 publications with EGFR and Brain
 Skin Antibodies  >754 publications with EGFR and Skin
 Liver Antibodies  >648 publications with EGFR and Liver
 Heart Antibodies  >503 publications with EGFR and Heart
 Prostate Antibodies  >484 publications with EGFR and Prostate
 Muscle Antibodies  >439 publications with EGFR and Muscle
 Eye Antibodies  >328 publications with EGFR and Eye
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