View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-ERBB2IP antibody :: Rabbit anti-Human Erbin Polyclonal Antibody Catalog # MBS9508512 Unit / Price 0.05 mL / $285 +1 FREE 8GB USB 0.1 mL / $365 +1 FREE 8GB USB 5x0.1 mL / $1,435 +1 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Erbin (ERBB2IP), Polyclonal Antibody Popular Item Full Product Name Erbin (Phospho-Tyr1104) Antibody Product Gene Name anti-ERBB2IP antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM AF263744 mRNA 3D Structure ModBase 3D Structure for Q96RT1 Clonality Polyclonal Host Rabbit Species Reactivity Human Specificity Erbin (Phospho-Tyr1104) antibody detects endogenous levels of Erbin only when phosphorylated at Tyr1104. Purity/Purification Purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide. Form/Format Rabbit IgG in phosphate buffered saline (Phospho-without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Concentration 1 mg/ml (lot specific) Target Modification Phospho Modification Sites H:Y1104 Immunogen The antiserum was produced against synthesized phospho-peptide derived from human Erbin around the phosphorylation site of Tyr1104. Preparation and Storage Stable at -20 degree C for at least 1 year. Other Notes Small volumes of anti-ERBB2IP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Applications Tested/Suitable for anti-ERBB2IP antibody Western Blot (WB), ELISA (EIA) Application Notes for anti-ERBB2IP antibody WB: 1:500~1:1000ELISA: 1:10000 ELISA (EIA) of anti-ERBB2IP antibody Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Erbin (Phospho-Tyr1104) Antibody Western Blot (WB) of anti-ERBB2IP antibody Western blot analysis of lysates from HeLa cells, using phospho-Erbin (Phospho-Tyr1104) antibody. TOP NCBI/Uniprot data below describe general gene information for ERBB2IP. It may not necessarily be applicable to this product. NCBI GI # 55770895 NCBI GeneID 55914 NCBI Accession # NP_001006600.1 [Other Products] NCBI GenBank Nucleotide # NM_001006600.2 [Other Products] UniProt Primary Accession # Q96RT1 [Other Products] UniProt Secondary Accession # Q1RMD0; Q86W38; Q9NR18; Q9NW48; Q9ULJ5; A0AVR1; B4E3F1; B7ZLV9; E7EQW9; E9PCR8[Other Products] UniProt Related Accession # Q96RT1[Other Products] Molecular Weight 158 kDa TOP NCBI Official Full Name erbin isoform 7 NCBI Official Synonym Full Names erbb2 interacting protein NCBI Official Symbol ERBIN [Similar Products] NCBI Official Synonym Symbols LAP2; ERBB2IP; HEL-S-78 [Similar Products] NCBI Protein Information erbin; protein LAP2 UniProt Protein Name Erbin UniProt Synonym Protein Names Densin-180-like protein; Erbb2-interacting protein Protein Family Erbin UniProt Gene Name ERBIN [Similar Products] TOP NCBI Summary for ERBB2IP This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] TOP UniProt Comments for ERBB2IP Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728). Research Articles on ERBB2IP 1. STAT3 activation promotes ERBIN expression and negatively regulates TGF-beta activity by the formation of a STAT3-ERBIN-SMAD2/3 complex. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. 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TOP Products associated with anti-ERBB2IP antibody Reference Product PubMed Publications ERBB2 antibody >42 publications with ERBB2IP and ERBB2 NOD2 antibody >4 publications with ERBB2IP and NOD2 NRG1 antibody >3 publications with ERBB2IP and NRG1 PKP4 antibody >3 publications with ERBB2IP and PKP4 SRC antibody >1 publications with ERBB2IP and SRC ARVCF antibody >1 publications with ERBB2IP and ARVCF Pathways associated with anti-ERBB2IP antibody Products by Pathway Pathway Diagram Alpha6-Beta4 Integrin Signaling Pathway antibodies Alpha6-Beta4 Integrin Signaling Pathway Diagram NLR Proteins Pathway antibodies NLR Proteins Pathway Diagram NOD Pathway antibodies NOD Pathway Diagram NOD-like Receptor Signaling Pathway antibodies NOD-like Receptor Signaling Pathway Diagram NOD-like Receptor Signaling Pathway antibodies NOD-like Receptor Signaling Pathway Diagram Signal Transduction Pathway antibodies Signal Transduction Pathway Diagram Signaling By ERBB2 Pathway antibodies Signaling By ERBB2 Pathway Diagram TGF-beta Receptor Signaling Pathway antibodies TGF-beta Receptor Signaling Pathway Diagram Diseases associated with anti-ERBB2IP antibody Disease Name Pubmed Publications Carcinoma Antibodies >11 publications with ERBB2IP and Carcinoma Cardiovascular Diseases Antibodies >4 publications with ERBB2IP and Cardiovascular Diseases Precancerous Conditions Antibodies >2 publications with ERBB2IP and Precancerous Conditions Inflammation Antibodies >2 publications with ERBB2IP and Inflammation Nervous System Diseases Antibodies >2 publications with ERBB2IP and Nervous System Diseases Lung Neoplasms Antibodies >1 publications with ERBB2IP and Lung Neoplasms Urinary Bladder Neoplasms Antibodies >1 publications with ERBB2IP and Urinary Bladder Neoplasms Hypertrophy Antibodies >1 publications with ERBB2IP and Hypertrophy Respiratory Tract Diseases Antibodies >1 publications with ERBB2IP and Respiratory Tract Diseases Necrosis Antibodies >1 publications with ERBB2IP and Necrosis Organs/Tissues associated with anti-ERBB2IP antibody Organ/Tissue Name Pubmed Publications Nerve Antibodies >10 publications with ERBB2IP and Nerve Kidney Antibodies >4 publications with ERBB2IP and Kidney Heart Antibodies >4 publications with ERBB2IP and Heart Blood Antibodies >4 publications with ERBB2IP and Blood Brain Antibodies >4 publications with ERBB2IP and Brain Intestine Antibodies >3 publications with ERBB2IP and Intestine Skin Antibodies >3 publications with ERBB2IP and Skin Liver Antibodies >2 publications with ERBB2IP and Liver Muscle Antibodies >2 publications with ERBB2IP and Muscle Prostate Antibodies >2 publications with ERBB2IP and Prostate TOP © 2006-24 MyBioSource.com. 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