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anti-EPB42 antibody :: Rabbit anti-Human Erythrocyte Membrane Protein Band 4.2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2027977 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $340 +1 FREE 8GB USB
1 mg  /  $800 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Erythrocyte Membrane Protein Band 4.2 (EPB42), Polyclonal Antibody

 Also Known As   

Polyclonal Antibody to Erythrocyte Membrane Protein Band 4.2 (EPB42)

 Product Gene Name   

anti-EPB42 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M60298 mRNA
 3D Structure    ModBase 3D Structure for P16452
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against EPB42. It has beenselected for its ability to recognize EPB42 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    EPB42 (Leu475~Ala686)
 Organism Species    Homo sapiens (Human)
 Conjugate    No Conjugate
 Immunogen    Recombinant EPB42 (Leu475~Ala686) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2076017
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-EPB42 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EPB42 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-EPB42 antibody    Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-EPB42 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-EPB42 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-EPB42 antibody    (Figure.DAB staining on IHC-P. Samples: Human Tissue)
anti-EPB42 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for EPB42. It may not necessarily be applicable to this product.
 NCBI GI #    166362735
 NCBI GeneID    2038
 NCBI Accession #    NP_000110.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000119.2 [Other Products]
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 UniProt Primary Accession #    P16452 [Other Products]
 UniProt Secondary Accession #    Q4KKX0; Q4VB97 [Other Products]
 UniProt Related Accession #    P16452 [Other Products]
 Molecular Weight    69,455 Da
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 NCBI Official Full Name    erythrocyte membrane protein band 4.2 isoform 1
 NCBI Official Synonym Full Names    erythrocyte membrane protein band 4.2
 NCBI Official Symbol    EPB42 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    erythrocyte membrane protein band 4.2
 UniProt Protein Name    Erythrocyte membrane protein band 4.2
 Protein Family    Erythrocyte membrane protein
 UniProt Gene Name    EPB42 [Similar Products]
 UniProt Synonym Gene Names    E42P; Erythrocyte protein 4.2; P4.2 [Similar Products]
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 NCBI Summary for EPB42    Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EPB42    Epb4.2: Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. Defects in EPB42 are the cause of spherocytosis type 5 (SPH5); also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported. Belongs to the transglutaminase superfamily. Transglutaminase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 15q15.2

Cellular Component: cortical cytoskeleton; cytoskeleton; plasma membrane

Molecular Function: ATP binding; protein binding; protein-glutamine gamma-glutamyltransferase activity; structural constituent of cytoskeleton

Biological Process: cell morphogenesis; cytoskeleton organization; erythrocyte maturation; hemoglobin metabolic process; iron ion homeostasis; peptide cross-linking; regulation of cell shape; spleen development

Disease: Spherocytosis, Type 5
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 Research Articles on EPB42    1. study shows that cytoplasmic hereditary spherocytosis mutants cause impaired binding of protein 4.2 to AE1, leaving protein 4.2 susceptible to loss during erythrocyte development
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EPB42 antibodyOrgans/Tissues associated with anti-EPB42 antibody
 Reference Product  PubMed Publications
 ANK1 antibody  >3 publications with EPB42 and ANK1
 EPB41 antibody  >2 publications with EPB42 and EPB41
 CD47 antibody  >2 publications with EPB42 and CD47
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with EPB42 and Blood
 Embryonic Tissue Antibodies  >1 publications with EPB42 and Embryonic Tissue
 Connective Tissue Antibodies  >1 publications with EPB42 and Connective Tissue
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