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anti-EPOR antibody :: Rabbit anti-Mouse Erythropoietin Receptor (EPOR) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2003566 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $170 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $315 +1 FREE 8GB USB
1 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Erythropoietin Receptor (EPOR), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Erythropoietin Receptor (EPOR)

 Product Gene Name   

anti-EPOR antibody

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 Matching Pairs    Antibody: Erythropoietin Receptor (EPOR) (MBS2003566)
Antigen: Erythropoietin Receptor (EPOR) (MBS2012228)
 Matching Pairs    Unconjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2003566)
APC-CY7 Conjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2035353)
 Matching Pairs    Unconjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2003566)
PE Conjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2035354)
 Matching Pairs    Unconjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2003566)
APC-CY7 Conjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2035355)
 Matching Pairs    Unconjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2003566)
Cy3 Conjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2035356)
 Matching Pairs    Unconjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2003566)
FITC Conjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2035357)
 Matching Pairs    Unconjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2003566)
HRP Conjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2035358)
 Matching Pairs    Unconjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2003566)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Erythropoietin Receptor (EPOR) (MBS2003566)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-RGSEEL LCFTQRLEDL VCFWEEAASS GMDFNYSFSY QLEGESRKSC SLHQAPTVRG SVRFWCSLPT ADTSSFVPLE LQVTEASGSP RYHRIIHINE VVLLDAPAGL LARRAEEGSH VVLRWLPPPG APMTTHIRYE VDVSAGNRAG GTQRVEVLEG RTECVLSNLR GGTRYTFAVR ARMAEPSFSG FWSAWSEPAS LLTA
 3D Structure    ModBase 3D Structure for P14753
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    The antibody is a rabbit polyclonal antibody raised against EPOR. It has been selected for its ability to recognize EPOR in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant EPOR (Arg45~Ala244) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2035355
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-EPOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EPOR antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-EPOR antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-EPOR antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-EPOR antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-EPOR antibody    (Figure.DAB staining on IHC-P. Samples: Mouse Tissue)
anti-EPOR antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for EPOR. It may not necessarily be applicable to this product.
 NCBI GI #    116292186
 NCBI GeneID    13857
 NCBI Accession #    NP_034279.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_010149.3 [Other Products]
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 UniProt Primary Accession #    P14753 [Other Products]
 UniProt Secondary Accession #    Q63852 [Other Products]
 UniProt Related Accession #    P14753 [Other Products]
 Molecular Weight    28,798 Da
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 NCBI Official Full Name    erythropoietin receptor
 NCBI Official Synonym Full Names    erythropoietin receptor
 NCBI Official Symbol    Epor [Similar Products]
 NCBI Protein Information    erythropoietin receptor
 UniProt Protein Name    Erythropoietin receptor
 Protein Family    Erythropoietin receptor
 UniProt Gene Name    Epor [Similar Products]
 UniProt Synonym Gene Names    EPO-R [Similar Products]
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 UniProt Comments for EPOR    EPOR: erythropoietin receptor: a member of the cytokine receptor family. Mediates erythropoietin-induced erythroblast proliferation, differentiation and survival. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. Forms homodimers on EPO stimulation. Tyrosine-phosphorylated EpoR may bind several SH2 domain-containing proteins including LYN, the adapter protein APS, SHP-1, SHP-2, JAK2, PI3 kinases, STAT5A/B, SOCS3, and CRKL. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Three alternatively-spliced isoforms have been described. Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 9 A3|9 7.93 cM

Cellular Component: cytoplasm; external side of plasma membrane; extracellular region; integral component of membrane; membrane; plasma membrane

Molecular Function: erythropoietin receptor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; identical protein binding; protein binding; transmembrane receptor activity

Biological Process: brain development; cardiac muscle morphogensis; decidualization; elevation of cytosolic calcium ion concentration; embryonic development; heart development; heart morphogenesis; negative regulation of neuron apoptosis; negative regulation of nitric oxide biosynthetic process; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; signal transduction; ventricular cardiac muscle tissue morphogenesis; viral process
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 Research Articles on EPOR    1. CIS interacted with phosphorylated EpoR at Y401, which was critical for the activation of STAT5 and ERK.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EPOR antibodyPathways associated with anti-EPOR antibody
 Reference Product  PubMed Publications
 EPO antibody  >616 publications with EPOR and EPO
 JAK2 antibody  >162 publications with EPOR and JAK2
 KITLG antibody  >93 publications with EPOR and KITLG
 KIT antibody  >45 publications with EPOR and KIT
 MAPK3 antibody  >15 publications with EPOR and MAPK3
 PTPN6 antibody  >13 publications with EPOR and PTPN6
 MAPK1 antibody  >13 publications with EPOR and MAPK1
 STAT5A antibody  >12 publications with EPOR and STAT5A
 PTPN11 antibody  >10 publications with EPOR and PTPN11
 GRB2 antibody  >9 publications with EPOR and GRB2
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with anti-EPOR antibodyOrgans/Tissues associated with anti-EPOR antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >164 publications with EPOR and Anemia
 Polycythemia Antibodies  >78 publications with EPOR and Polycythemia
 Cardiovascular Diseases Antibodies  >70 publications with EPOR and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >59 publications with EPOR and Disease Models, Animal
 Kidney Diseases Antibodies  >36 publications with EPOR and Kidney Diseases
 Breast Neoplasms Antibodies  >32 publications with EPOR and Breast Neoplasms
 Inflammation Antibodies  >28 publications with EPOR and Inflammation
 Necrosis Antibodies  >28 publications with EPOR and Necrosis
 Adenocarcinoma Antibodies  >28 publications with EPOR and Adenocarcinoma
 Heart Diseases Antibodies  >19 publications with EPOR and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >295 publications with EPOR and Blood
 Bone Antibodies  >112 publications with EPOR and Bone
 Brain Antibodies  >92 publications with EPOR and Brain
 Kidney Antibodies  >61 publications with EPOR and Kidney
 Liver Antibodies  >60 publications with EPOR and Liver
 Heart Antibodies  >36 publications with EPOR and Heart
 Embryonic Tissue Antibodies  >28 publications with EPOR and Embryonic Tissue
 Lung Antibodies  >21 publications with EPOR and Lung
 Eye Antibodies  >20 publications with EPOR and Eye
 Skin Antibodies  >10 publications with EPOR and Skin
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