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anti-Esr2 antibody :: Rabbit Estrogen, Total Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS620830 anti-Esr2 antibody
Unit / Price
1000 Tests  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Estrogen, Total (Esr2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Estrogen, Total

 Product Synonym Names    Anti -Estrogen, Total
 Product Gene Name   

anti-Esr2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_005105.3 (108576433..108625992, complement). Location: 6q24
 3D Structure    ModBase 3D Structure for Q62986
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Specificity    Recognizes total Estrogen: 100%.
 Purity/Purification    Serum
Serum
 Form/Format    Supplied as a liquid. No preservatives added
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 Immunogen    Estriol (BSA)
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-Esr2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Esr2 antibody    Antibodies; Abs to Hormones, Steroids
 Applications Tested/Suitable for anti-Esr2 antibody   

ELISA (EL/EIA), Radioimmunoassay (RIA)

 Application Notes for anti-Esr2 antibody    Suitable for use in RIA and ELISA.
Dilution: RIA: 33,000test/ml
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NCBI/Uniprot data below describe general gene information for Esr2. It may not necessarily be applicable to this product.
 NCBI GI #    3077649
 NCBI GeneID    25149
 NCBI Accession #    CAA05631.1 [Other Products]
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 UniProt Primary Accession #    Q62986 [Other Products]
 UniProt Secondary Accession #    O35784; O35785; O55015; O55016; O70195; Q9R185 [Other Products]
 UniProt Related Accession #    Q62986 [Other Products]
 Molecular Weight    59,152 Da [Similar Products]
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 NCBI Official Full Name    estrogen receptor beta
 NCBI Official Synonym Full Names    estrogen receptor 2 (ER beta)
 NCBI Official Symbol    Esr2 [Similar Products]
 NCBI Official Synonym Symbols   
Erb2; ERbeta; ER-beta
[Similar Products]
 NCBI Protein Information    estrogen receptor beta; estrogen receptor 2 beta; nuclear receptor subfamily 3 group A member 2
 UniProt Protein Name    Estrogen receptor beta
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 3 group A member 2
 Protein Family    Estrogen receptor
 UniProt Gene Name    Esr2 [Similar Products]
 UniProt Synonym Gene Names    Erbeta; Nr3a2; ER-beta [Similar Products]
 UniProt Entry Name    ESR2_RAT
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 NCBI Summary for Esr2    binds estrogen and mediates transcriptional activation [RGD, Feb 2006]
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 UniProt Comments for Esr2    ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: Nuclear receptor; DNA-binding

Cellular Component: neuron projection; cell soma; mitochondrion; perinuclear region of cytoplasm; cytoplasm; plasma membrane; perikaryon; nucleus; cilium

Molecular Function: peroxisome proliferator activated receptor binding; ligand-dependent nuclear receptor activity; estrogen receptor activity; hormone binding; zinc ion binding; estrogen response element binding; drug binding; steroid binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity

Biological Process: prostate gland development; hypothalamus development; behavioral fear response; estrogen receptor signaling pathway; negative regulation of smooth muscle cell proliferation; positive regulation of apoptosis; induction of apoptosis by hormones; positive regulation of transcription, DNA-dependent; response to hormone stimulus; neuron migration; amygdala development; negative regulation of transcription from RNA polymerase II promoter; response to insecticide; uterus development; response to organic cyclic substance; response to estradiol stimulus; negative regulation of cell proliferation; learning and/or memory; ovarian follicle development; regulation of transcription, DNA-dependent; positive regulation of epidermal growth factor receptor signaling pathway; regulation of neuron apoptosis; cerebellum development; female gonad development; negative regulation of epithelial cell proliferation; response to nutrient levels; response to drug; steroid hormone receptor signaling pathway; transcription, DNA-dependent; male gonad development; vagina development; Sertoli cell proliferation; response to testosterone stimulus; Sertoli cell development; regulation of cell proliferation; response to genistein; response to ethanol; response to estrogen stimulus; positive regulation of transcription factor activity; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; response to activity; brain development; negative regulation of behavior; response to water deprivation
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 Research Articles on Esr2    1. Estrogen receptor beta increases in males only in a model of disordered occlusion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Esr2 antibodyDiseases associated with anti-Esr2 antibody
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >77 publications with Esr2 and Neoplasms
 Breast Neoplasms Antibodies  >27 publications with Esr2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >27 publications with Esr2 and Cardiovascular Diseases
 Genital Diseases, Male Antibodies  >22 publications with Esr2 and Genital Diseases, Male
 Colorectal Neoplasms Antibodies  >13 publications with Esr2 and Colorectal Neoplasms
 Endometriosis Antibodies  >11 publications with Esr2 and Endometriosis
 Infertility, Female Antibodies  >11 publications with Esr2 and Infertility, Female
 Congenital Abnormalities Antibodies  >10 publications with Esr2 and Congenital Abnormalities
 Hypertension Antibodies  >10 publications with Esr2 and Hypertension
 Carcinoma Antibodies  >10 publications with Esr2 and Carcinoma
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