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anti-VIL2 antibody :: Goat Ezrin/villin 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420129
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ezrin/villin 2 (VIL2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Ezrin/villin 2 Antibody

 Product Synonym Names    villin 2 (ezrin); ezrin; VIL2; CVIL; CVL; DKFZp762H157; FLJ26216; MGC1584; cytovillin; villin 2; villin 2 (ezrin) antibody; ezrin antibody; VIL2 antibody; CVIL antibody; CVL antibody; DKFZp762H157 antibody; FLJ26216 antibody; MGC1584 antibody; cytovillin antibody; villin 2 antibody; Ezrin; Villin 2; Ezrin / villin 2
 Product Gene Name   

anti-VIL2 antibody

[Similar Products]
 Antibody/Peptide Pairs    Ezrin / villin 2 peptide (MBS425810) is used for blocking the activity of Ezrin/villin 2 antibody (MBS420129)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QDYEEKTKKA ER
 OMIM    123900
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
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 Immunogen    Peptide with sequence C-QDYEEKTKKAER, from the internal region of the protein sequence according to NP_003370.2.
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 Preparation and Storage    Aliquot and store at -20C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-VIL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-VIL2 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-VIL2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.


Western Blot: Approx 80kDa band observed in Human Placenta Lysates.(calculated MW of 69.4kDa according to NP_003370.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Zhu et al, Am J Physiol Cell Physiol.2005 Jun;288(6): C1242-54.; PMID: 15788482). Recommended concentration: 1-3ug/ml.

Immunohistochemistry: In paraffin embedded Human Small Intestine shows strong staining of enterocytes.
Recommended concentration, 3-5ug/ml.Paraffin embedded Human Kidney.
Recommended concentration: 3.75 mg/mL
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 Western Blot (WB) of anti-VIL2 antibody    (1ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-VIL2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-VIL2 antibody    (3.8ug/ml) staining of paraffin embedded Human Small Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-VIL2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for VIL2. It may not necessarily be applicable to this product.
 NCBI GI #    21614499
 NCBI GeneID    7430
 NCBI Accession #    NP_003370.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003379.4 [Other Products]
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 UniProt Secondary Accession #    P23714; Q4VX75; Q96CU8; Q9NSJ4; E1P5A8 [Other Products]
 UniProt Related Accession #    P15311 [Other Products]
 Molecular Weight    69,413 Da
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 NCBI Official Full Name    ezrin
 NCBI Official Synonym Full Names    ezrin
 NCBI Official Symbol    EZR [Similar Products]
 NCBI Official Synonym Symbols   
CVL; CVIL; VIL2; HEL-S-105
[Similar Products]
 NCBI Protein Information    ezrin
 UniProt Protein Name    Ezrin
 UniProt Synonym Protein Names   
Cytovillin; Villin-2; p81
 Protein Family    VIN3-like protein
 UniProt Gene Name    EZR [Similar Products]
 UniProt Synonym Gene Names    VIL2 [Similar Products]
 UniProt Entry Name    EZRI_HUMAN
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 NCBI Summary for VIL2    The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VIL2    Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: actin cytoskeleton; actin filament; apical part of cell; apical plasma membrane; basolateral plasma membrane; brush border; cell projection; cortical cytoskeleton; cytoplasm; cytosol; endosome; extracellular space; extrinsic to membrane; filopodium; focal adhesion; immunological synapse; membrane; microvillus; microvillus membrane; myelin sheath; nucleolus; perinuclear region of cytoplasm; plasma membrane; ruffle; T-tubule; uropod; vesicle

Molecular Function: actin binding; actin filament binding; ATPase binding; cell adhesion molecule binding; microtubule binding; protein binding; protein domain specific binding

Biological Process: actin cytoskeleton reorganization; actin filament bundle formation; astral microtubule organization and biogenesis; axon guidance; cortical microtubule organization and biogenesis; cytoskeletal anchoring; D-glucose absorption; establishment of centrosome localization; establishment of epithelial cell polarity; filopodium formation; gland morphogenesis; leukocyte adhesion; membrane to membrane docking; microvillus biogenesis; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; phosphoinositide-mediated signaling; positive regulation of multicellular organism growth; positive regulation of protein secretion; receptor internalization; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of cell size; regulation of microvillus length
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 Research Articles on VIL2    1. These findings are important in understanding the interrelation and dynamics of a CHP1-ezrin-NHE3 regulatory complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VIL2 antibodyPathways associated with anti-VIL2 antibody
 Reference Product  PubMed Publications
 PRKCA antibody  >3 publications with VIL2 and PRKCA
 ICAM1 antibody  >1 publications with VIL2 and ICAM1
 SLC9A3R1 antibody  >1 publications with VIL2 and SLC9A3R1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 FAS (CD95) Signaling Pathway antibodies  FAS (CD95) Signaling Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
Diseases associated with anti-VIL2 antibodyOrgans/Tissues associated with anti-VIL2 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >15 publications with VIL2 and Carcinoma
 Lung Neoplasms Antibodies  >9 publications with VIL2 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >6 publications with VIL2 and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >3 publications with VIL2 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with VIL2 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >2 publications with VIL2 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >2 publications with VIL2 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >2 publications with VIL2 and Disease Models, Animal
 Hypertension Antibodies  >1 publications with VIL2 and Hypertension
 Liver Neoplasms Antibodies  >1 publications with VIL2 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >12 publications with VIL2 and Lung
 Bone Antibodies  >5 publications with VIL2 and Bone
 Lymph Node Antibodies  >4 publications with VIL2 and Lymph Node
 Blood Antibodies  >4 publications with VIL2 and Blood
 Lymph Antibodies  >4 publications with VIL2 and Lymph
 Vascular Antibodies  >3 publications with VIL2 and Vascular
 Thyroid Antibodies  >3 publications with VIL2 and Thyroid
 Brain Antibodies  >3 publications with VIL2 and Brain
 Heart Antibodies  >2 publications with VIL2 and Heart
 Eye Antibodies  >2 publications with VIL2 and Eye
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