EAW80563.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,707 Da
NCBI Official Full Name
F-box and leucine-rich repeat protein 3
NCBI Official Synonym Full Names
F-box and leucine rich repeat protein 3
NCBI Protein Information
F-box/LRR-repeat protein 3
UniProt Protein Name
F-box/LRR-repeat protein 3
UniProt Synonym Protein Names
F-box and leucine-rich repeat protein 3A; F-box/LRR-repeat protein 3A
UniProt Synonym Gene Names
NCBI Summary for FBXL3
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]
UniProt Comments for FBXL3
FBXL3: Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 13q22.3
Cellular Component: cytosol; nucleus; SCF ubiquitin ligase complex
Molecular Function: protein binding; ubiquitin-protein ligase activity
Biological Process: entrainment of circadian clock by photoperiod; protein destabilization; protein ubiquitination; regulation of circadian rhythm; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Research Articles on FBXL3
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Products associated with anti-FBXL3 antibody
Pathways associated with anti-FBXL3 antibody
Diseases associated with anti-FBXL3 antibody
Organs/Tissues associated with anti-FBXL3 antibody
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