NP_001013433.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,120 Da
NCBI Official Full Name
F-box/WD repeat-containing protein 7 isoform 3
NCBI Official Synonym Full Names
F-box and WD repeat domain containing 7
NCBI Official Synonym Symbols
AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10 [Similar Products]
NCBI Protein Information
F-box/WD repeat-containing protein 7
UniProt Protein Name
F-box/WD repeat-containing protein 7
UniProt Synonym Protein Names
Archipelago homolog
UniProt Synonym Gene Names
NCBI Summary for FBXW7
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for FBXW7
FBXW7: a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including MYC, cyclin E, NOTCH1-released notch intracellular domain (NICD), JUN, and probably PSEN1. Recognizes and binds to phosphorylated target proteins. Other components of the SCF(FBXW7) complex are sCUL1, RBX1, and SKP1A. Defects in FBXW7 may be a cause of breast cancer. The homolog of Cdc4, one of the yeast genes that regulate sister chromatid cohesion. Down-regulation or disruption of FBXW7 resulted in abnormal sister chromatid cohesion in human cells. Four alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Nucleolus; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4q31.3
Cellular Component: cytoplasm; cytosol; nucleolus; nucleoplasm; Parkin-FBXW7-Cul1 ubiquitin ligase complex; SCF ubiquitin ligase complex
Molecular Function: cyclin binding; identical protein binding; phosphothreonine residue binding; protein binding; protein binding, bridging; ubiquitin protein ligase binding; ubiquitin-protein transferase activity
Biological Process: lipid homeostasis; negative regulation of DNA endoreduplication; negative regulation of hepatocyte proliferation; negative regulation of Notch signaling pathway; negative regulation of SREBP signaling pathway; negative regulation of triglyceride biosynthetic process; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of protein targeting to mitochondrion; positive regulation of protein ubiquitination; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein transferase activity; post-translational protein modification; protein polyubiquitination; protein stabilization; protein ubiquitination; regulation of cell cycle G1/S phase transition; regulation of lipid storage; regulation of protein localization; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; sister chromatid cohesion; vasculature development; viral process
Research Articles on FBXW7
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-FBXW7 antibody
Pathways associated with anti-FBXW7 antibody
Diseases associated with anti-FBXW7 antibody
Organs/Tissues associated with anti-FBXW7 antibody
|