NP_536353.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,547 Da
NCBI Official Full Name
F-box/WD repeat-containing protein 7 isoform 2
NCBI Official Synonym Full Names
F-box and WD-40 domain protein 7
NCBI Official Synonym Symbols
AGO; Cdc4; Fbw7; Fbwd6; Fbx30; Fbxw6; Fbxo30; SEL-10; 1110001A17Rik [Similar Products]
NCBI Protein Information
F-box/WD repeat-containing protein 7
UniProt Protein Name
F-box/WD repeat-containing protein 7
UniProt Synonym Protein Names
F-box and WD-40 domain-containing protein 7
UniProt Comments for FBXW7
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation.
Research Articles on FBXW7
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Products associated with anti-FBXW7 antibody
Pathways associated with anti-FBXW7 antibody
Diseases associated with anti-FBXW7 antibody
Organs/Tissues associated with anti-FBXW7 antibody
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