NP_006127.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,775 Da
NCBI Official Full Name
F-actin-capping protein subunit alpha-2
NCBI Official Synonym Full Names
capping actin protein of muscle Z-line alpha subunit 2
NCBI Official Synonym Symbols
NCBI Protein Information
F-actin-capping protein subunit alpha-2
UniProt Protein Name
F-actin-capping protein subunit alpha-2
UniProt Synonym Protein Names
CapZ alpha-2
UniProt Entry Name
CAZA2_HUMAN
NCBI Summary for CAPZA2
The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
UniProt Comments for CAPZA2
CAPZA2: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Belongs to the F-actin-capping protein alpha subunit family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.2-q31.3
Cellular Component: actin cytoskeleton; brush border; cortical cytoskeleton; cytosol; extracellular region; F-actin capping protein complex; membrane
Molecular Function: actin binding
Biological Process: barbed-end actin filament capping; blood coagulation; cell motility; innate immune response; protein complex assembly
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Products associated with anti-CAPZA2 antibody
Pathways associated with anti-CAPZA2 antibody
Diseases associated with anti-CAPZA2 antibody
Organs/Tissues associated with anti-CAPZA2 antibody
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