AAH26213.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
F-box and WD repeat domain containing 11
NCBI Official Synonym Full Names
F-box and WD repeat domain containing 11
NCBI Official Synonym Symbols
Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B [Similar Products]
NCBI Protein Information
F-box/WD repeat-containing protein 11; F-box protein Fbw1b; homologous to Slimb protein; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box/WD repeat-containing protein 1B; F-box and WD repeats protein beta-TrCP2; beta-transducin repeat-containing protein 2
UniProt Protein Name
F-box/WD repeat-containing protein 11
UniProt Synonym Protein Names
F-box and WD repeats protein beta-TrCP2; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein; HOS
UniProt Synonym Gene Names
UniProt Entry Name
FBW1B_HUMAN
NCBI Summary for FBXW11
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
UniProt Comments for FBXW11
FBW1B: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: centrosome; SCF ubiquitin ligase complex; cytosol; nucleus; ubiquitin ligase complex
Molecular Function: protein dimerization activity; protein binding; ubiquitin-protein ligase activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; protein polyubiquitination; protein destabilization; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; rhythmic process; protein ubiquitination; positive regulation of circadian rhythm; negative regulation of NF-kappaB import into nucleus; protein amino acid dephosphorylation; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent
Research Articles on FBXW11
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Products associated with anti-FBXW11 antibody
Pathways associated with anti-FBXW11 antibody
Diseases associated with anti-FBXW11 antibody
Organs/Tissues associated with anti-FBXW11 antibody
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