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anti-F5 antibody :: Rabbit anti-Human F5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7044721
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

F5, Polyclonal Antibody

★Popular Item★
 Also Known As   

F5 Antibody

 Product Synonym Names    Coagulation factor V; Activated protein C cofactor; Proaccelerin; labile factor; Coagulation factor V; F5
 Product Gene Name   

anti-F5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    188055
 3D Structure    ModBase 3D Structure for P12259
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Coagulation factor V protein (1490-1614AA)
 Conjugate    Non-conjugated
 Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16335 / sc-16336
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-F5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-F5 antibody

   Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
 Applications Tested/Suitable for anti-F5 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-F5 antibody    Immunohistochemistry of paraffin-embedded human liver cancer using MBS7044721 at dilution of 1:100
anti-F5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-F5 antibody    Immunofluorescent analysis of HepG-2 cells using MBS7044721 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-F5 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for F5. It may not necessarily be applicable to this product.
 NCBI GI #    105990535
 NCBI GeneID    2153
 NCBI Accession #    NP_000121.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000130.4 [Other Products]
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 UniProt Primary Accession #    P12259 [Other Products]
 UniProt Secondary Accession #    Q14285; Q2EHR5; Q5R346; Q5R347; Q6UPU6; Q8WWQ6; A8K6E8 [Other Products]
 UniProt Related Accession #    P12259 [Other Products]
 Molecular Weight    251,703 Da
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 NCBI Official Full Name    coagulation factor V preproprotein
 NCBI Official Synonym Full Names    coagulation factor V
 NCBI Official Symbol    F5 [Similar Products]
 NCBI Official Synonym Symbols   
FVL; PCCF; THPH2; RPRGL1
[Similar Products]
 NCBI Protein Information    coagulation factor V
 UniProt Protein Name    Coagulation factor V
 UniProt Synonym Protein Names   
Activated protein C cofactor; Proaccelerin, labile factor
 Protein Family    Coagulation factor
 UniProt Gene Name    F5 [Similar Products]
 UniProt Entry Name    FA5_HUMAN
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 NCBI Summary for F5    This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]
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 UniProt Comments for F5    factor V: Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. Defects in F5 are the cause of factor V deficiency (FA5D); also known as Owren parahemophilia. It is an hemorrhagic diastesis. Defects in F5 are the cause of thrombophilia due to activated protein C resistance (THPH2). THPH2 is a hemostatic disorder due to defective degradation of factor Va by activated protein C. It is characterized by a poor anticoagulant response to activated protein C resulting in tendency to thrombosis. Defects in F5 are a cause of susceptibility to Budd- Chiari syndrome (BDCHS). A syndrome caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava. Obstructions are generally caused by thrombosis and lead to hepatic congestion and ischemic necrosis. Clinical manifestations observed in the majority of patients include hepatomegaly, right upper quadrant pain and abdominal ascites. Budd-Chiari syndrome is associated with a combination of disease states including primary myeloproliferative syndromes and thrombophilia due to factor V Leiden, protein C deficiency and antithrombin III deficiency. Budd-Chiari syndrome is a rare but typical complication in patients with polycythemia vera. Defects in F5 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in F5 are associated with susceptibility to pregnancy loss, recurrent, type 1 (RPRGL1). RPRGL1 is a common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. Belongs to the multicopper oxidase family.

Protein type: Protease; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: endoplasmic reticulum lumen; ER to Golgi transport vesicle; ER-Golgi intermediate compartment membrane; extracellular region; membrane; plasma membrane

Molecular Function: protein binding

Biological Process: blood coagulation; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; platelet degranulation

Disease: Budd-chiari Syndrome; Factor V Deficiency; Pregnancy Loss, Recurrent, Susceptibility To, 1; Stroke, Ischemic; Thrombophilia Due To Activated Protein C Resistance
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 Research Articles on F5    1. Case Report: acquired FV inhibitor that developed in a patient after exposure to human thrombin used as a hemostatic agent during an otorhinolaryngology surgical procedure.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-F5 antibodyPathways associated with anti-F5 antibody
 Reference Product  PubMed Publications
 F10 antibody  >48 publications with F5 and F10
 PROC antibody  >26 publications with F5 and PROC
 SERPINE1 antibody  >13 publications with F5 and SERPINE1
 SERPINC1 antibody  >13 publications with F5 and SERPINC1
 VWF antibody  >8 publications with F5 and VWF
 PROS1 antibody  >6 publications with F5 and PROS1
 PLG antibody  >1 publications with F5 and PLG
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 Cargo Concentration In The ER Pathway antibodies  Cargo Concentration In The ER Pathway Diagram
 Common Pathway Of Fibrin Clot Formation antibodies  Common Pathway Of Fibrin Clot Formation Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Diseases associated with anti-F5 antibodyOrgans/Tissues associated with anti-F5 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >121 publications with F5 and Cardiovascular Diseases
 Thrombosis Antibodies  >77 publications with F5 and Thrombosis
 Blood Coagulation Disorders Antibodies  >43 publications with F5 and Blood Coagulation Disorders
 Venous Thrombosis Antibodies  >40 publications with F5 and Venous Thrombosis
 Thromboembolism Antibodies  >35 publications with F5 and Thromboembolism
 Inflammation Antibodies  >35 publications with F5 and Inflammation
 Venous Thromboembolism Antibodies  >32 publications with F5 and Venous Thromboembolism
 Liver Diseases Antibodies  >28 publications with F5 and Liver Diseases
 Factor V Deficiency Antibodies  >25 publications with F5 and Factor V Deficiency
 Stroke Antibodies  >22 publications with F5 and Stroke
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >398 publications with F5 and Blood
 Brain Antibodies  >218 publications with F5 and Brain
 Liver Antibodies  >68 publications with F5 and Liver
 Heart Antibodies  >46 publications with F5 and Heart
 Thymus Antibodies  >44 publications with F5 and Thymus
 Lung Antibodies  >40 publications with F5 and Lung
 Intestine Antibodies  >38 publications with F5 and Intestine
 Kidney Antibodies  >34 publications with F5 and Kidney
 Eye Antibodies  >34 publications with F5 and Eye
 Embryonic Tissue Antibodies  >22 publications with F5 and Embryonic Tissue
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