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anti-FAM109A antibody :: Rabbit anti-Human FAM109A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9207877
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FAM109A, Polyclonal Antibody

★Popular Item★
 Also Known As   

FAM109A Antibody (N-term)

 Product Synonym Names    Sesquipedalian-1; Ses1; 27 kDa inositol polyphosphate phosphatase-interacting protein A; IPIP27A; FAM109A
 Product Gene Name   

anti-FAM109A antibody

[Similar Products]
 Antibody/Peptide Pairs    FAM109A peptide (MBS9218897) is used for blocking the activity of FAM109A antibody (MBS9207877)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    3-31
 3D Structure    ModBase 3D Structure for Q8N4B1
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB32032
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This FAM109A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-31 amino acids from the N-terminal region of human FAM109A.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Function    Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
 Cellular Location    Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin- coated vesicle. Note=Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes
    
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-FAM109A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FAM109A antibody

   This gene encodes a protein that localizes to the endosome and interacts with the enzyme, inositol polyphosphate 5-phosphatase OCRL-1. Alternate splicing results in multiple transcript variants.
 Applications Tested/Suitable for anti-FAM109A antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-FAM109A antibody    WB~~1:1000
IHC-P~~1:10~50
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 Western Blot (WB) of anti-FAM109A antibody    FAM109A Antibody (N-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the FAM109A antibody detected the FAM109A protein (arrow).
anti-FAM109A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-FAM109A antibody    FAM109A Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FAM109A Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-FAM109A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FAM109A. It may not necessarily be applicable to this product.
 NCBI GI #    295821165
 NCBI GeneID    144717
 NCBI Accession #    NP_001171467.1 [Other Products]
 NCBI Related Accession #    NP_001171468.1; NP_653272.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001177996.1 [Other Products]
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 UniProt Primary Accession #    Q8N4B1 [Other Products]
 UniProt Secondary Accession #    Q6PJL9; Q96MH8; J3KP50 [Other Products]
 UniProt Related Accession #    Q8N4B1 [Other Products]
 Molecular Weight    27215
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 NCBI Official Full Name    sesquipedalian-1 isoform 1
 NCBI Official Synonym Full Names    family with sequence similarity 109, member A
 NCBI Official Symbol    FAM109A [Similar Products]
 NCBI Official Synonym Symbols   
SES1; IPIP27A
[Similar Products]
 NCBI Protein Information    sesquipedalian-1
 UniProt Protein Name    Sesquipedalian-1
 UniProt Synonym Protein Names   
27 kDa inositol polyphosphate phosphatase-interacting protein A; IPIP27A
 Protein Family    Sesquipedalian
 UniProt Gene Name    FAM109A [Similar Products]
 UniProt Synonym Gene Names    Ses1; IPIP27A [Similar Products]
 UniProt Entry Name    SESQ1_HUMAN
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 NCBI Summary for FAM109A    This gene encodes a protein that localizes to the endosome and interacts with the enzyme, inositol polyphosphate 5-phosphatase OCRL-1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
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 UniProt Comments for FAM109A    FAM109A: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. Belongs to the sesquipedalian family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 12q24.12

Cellular Component: recycling endosome; clathrin-coated vesicle; early endosome; trans-Golgi network

Molecular Function: protein binding; protein homodimerization activity

Biological Process: receptor recycling; endosome organization and biogenesis; retrograde transport, endosome to Golgi
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Product References and Citations for anti-FAM109A antibody

   Swan, L.E., et al. Proc. Natl. Acad. Sci. U.S.A. 107(8):3511-3516(2010)
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 Research Articles on FAM109A    1. Two novel OCRL1-binding proteins, termed inositol polyphosphate phosphatase interacting protein of 27 kDa (IPIP27)A and B (also known as Ses1 and 2), that also bind the related 5-phosphatase Inpp5b, were identified.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FAM109A antibodyDiseases associated with anti-FAM109A antibody
 Reference Product  PubMed Publications
 OCRL antibody  >2 publications with FAM109A and OCRL
 INPP5B antibody  >1 publications with FAM109A and INPP5B
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with FAM109A and Kidney Diseases
Organs/Tissues associated with anti-FAM109A antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with FAM109A and Kidney
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