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anti-FANCD2 antibody :: Rabbit FANCD2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2534524
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FANCD2, Polyclonal Antibody

★Popular Item★
 Also Known As   

FANCD2 Polyclonal Antibody

 Product Synonym Names    FANCD2; FACD; Fanconi anemia group D2 protein; Protein FACD2
 Product Gene Name   

anti-FANCD2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    227646
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from human FANCD2 around the non-phosphorylation site of S222.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23584 / sc-28194
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FANCD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-FANCD2 antibody    Cancer
 Applications Tested/Suitable for anti-FANCD2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-FANCD2 antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-FANCD2 antibody    Western Blot analysis of various cells using FANCD2 Polyclonal Antibody at dilution of 1:500.
anti-FANCD2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FANCD2. It may not necessarily be applicable to this product.
 NCBI GI #    66528888
 NCBI GeneID    2177
 NCBI Accession #    NP_001018125.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001018115.2 [Other Products]
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 UniProt Secondary Accession #    Q2LA86; Q69YP9; Q6PJN7; Q9BQ06; Q9H9T9 [Other Products]
 UniProt Related Accession #    Q9BXW9 [Other Products]
 Molecular Weight    Calculated MW: 166
Observed MW: 166
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 NCBI Official Full Name    Fanconi anemia group D2 protein isoform b
 NCBI Official Synonym Full Names    Fanconi anemia complementation group D2
 NCBI Official Symbol    FANCD2 [Similar Products]
 NCBI Official Synonym Symbols   
FA4; FAD; FACD; FAD2; FA-D2; FANCD
[Similar Products]
 NCBI Protein Information    Fanconi anemia group D2 protein
 UniProt Protein Name    Fanconi anemia group D2 protein
 Protein Family    FANCD2 opposite strand protein
 UniProt Gene Name    FANCD2 [Similar Products]
 UniProt Synonym Gene Names    FACD; Protein FACD2 [Similar Products]
 UniProt Entry Name    FACD2_HUMAN
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 NCBI Summary for FANCD2    The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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 UniProt Comments for FANCD2    FANCD2: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. Interacts directly with FANCE and FANCI. Interacts with USP1 and MEN1. The ubiquitinated form specifically interacts with BRCA1 and BLM. Both the nonubiquitinated and the monoubiquitinated forms interact with BRCA2; this interaction is mediated by phosphorylated FANCG and the complex also includes XCCR3. The ubiquitinated form specifically interacts with MTMR15/FAN1 (via UBZ-type zinc finger), leading to recruit MTMR15/FAN1 to sites of DNA damage. Interacts with DCLRE1B/Apollo. Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas. Highly expressed in testis, where expression is restricted to maturing spermatocytes. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 3p26

Cellular Component: condensed chromosome; cytoplasm; nucleolus; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: DNA repair; gamete generation; response to gamma radiation; synapsis

Disease: Fanconi Anemia, Complementation Group D2; Tracheoesophageal Fistula With Or Without Esophageal Atresia
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 Research Articles on FANCD2    1. describe a mechanism of interstrand crosslink (ICL) sensing and propose that UHRF1 is a critical factor that binds to ICLs. In turn, this binding is necessary for the subsequent recruitment of FANCD2, which allows the DNA repair process to initiate
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FANCD2 antibodyPathways associated with anti-FANCD2 antibody
 Reference Product  PubMed Publications
 BRCA1 antibody  >149 publications with FANCD2 and BRCA1
 BRCA2 antibody  >129 publications with FANCD2 and BRCA2
 FANCA antibody  >124 publications with FANCD2 and FANCA
 FANCI antibody  >98 publications with FANCD2 and FANCI
 FANCC antibody  >91 publications with FANCD2 and FANCC
 ATM antibody  >66 publications with FANCD2 and ATM
 FANCL antibody  >57 publications with FANCD2 and FANCL
 FANCE antibody  >38 publications with FANCD2 and FANCE
 MRE11A antibody  >11 publications with FANCD2 and MRE11A
 Products by Pathway  Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-FANCD2 antibodyOrgans/Tissues associated with anti-FANCD2 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >613 publications with FANCD2 and Anemia
 Fanconi Anemia Antibodies  >613 publications with FANCD2 and Fanconi Anemia
 FANCONI ANEMIA, COMPLEMENTATION GROUP D2 Antibodies  >427 publications with FANCD2 and FANCONI ANEMIA, COMPLEMENTATION GROUP D2
 Breast Neoplasms Antibodies  >44 publications with FANCD2 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >22 publications with FANCD2 and Carcinoma, Squamous Cell
 Nervous System Diseases Antibodies  >18 publications with FANCD2 and Nervous System Diseases
 Brain Diseases Antibodies  >17 publications with FANCD2 and Brain Diseases
 Lung Neoplasms Antibodies  >16 publications with FANCD2 and Lung Neoplasms
 Disease Models, Animal Antibodies  >14 publications with FANCD2 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >13 publications with FANCD2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >133 publications with FANCD2 and Bone
 Bone Marrow Antibodies  >131 publications with FANCD2 and Bone Marrow
 Blood Antibodies  >64 publications with FANCD2 and Blood
 Lung Antibodies  >29 publications with FANCD2 and Lung
 Ovary Antibodies  >12 publications with FANCD2 and Ovary
 Brain Antibodies  >12 publications with FANCD2 and Brain
 Liver Antibodies  >9 publications with FANCD2 and Liver
 Kidney Antibodies  >8 publications with FANCD2 and Kidney
 Lymph Node Antibodies  >5 publications with FANCD2 and Lymph Node
 Lymph Antibodies  >5 publications with FANCD2 and Lymph
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