NP_114432.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Fanconi anemia group J protein
NCBI Official Synonym Full Names
BRCA1 interacting protein C-terminal helicase 1
NCBI Official Synonym Symbols
OF; BACH1; FANCJ; FLJ90232; MGC126521; MGC126523 [Similar Products]
NCBI Protein Information
Fanconi anemia group J protein; ATP-dependent RNA helicase BRIP1; BRCA1/BRCA2-associated helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1
UniProt Protein Name
Fanconi anemia group J protein
UniProt Synonym Protein Names
ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1
UniProt Synonym Gene Names
UniProt Entry Name
FANCJ_HUMAN
NCBI Summary for BRIP1
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq]
UniProt Comments for BRIP1
BRIP1: a DNA-dependent ATPase and DNA helicase required for the maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Binds directly to the BRCT domains of BRCA1. Defects in BRIP1 cause of susceptibility to breast cancer and Fanconi anemia. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Belongs to the DEAD box helicase family, DEAH subfamily. Two alternatively spliced human isoforms have been described.
Protein type: EC 3.6.4.13; Oncoprotein; Helicase
Chromosomal Location of Human Ortholog: 17q22.2
Cellular Component: nuclear membrane; cytoplasm; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; 4 iron, 4 sulfur cluster binding; metal ion binding; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; double-strand break repair; DNA damage checkpoint; DNA duplex unwinding
Disease: Fanconi Anemia, Complementation Group J; Breast Cancer; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Research Articles on BRIP1
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Products associated with anti-BRIP1 antibody
Pathways associated with anti-BRIP1 antibody
Diseases associated with anti-BRIP1 antibody
Organs/Tissues associated with anti-BRIP1 antibody
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