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anti-PLEKHA8 antibody :: Goat FAPP2/PLEKHA8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420752
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FAPP2/PLEKHA8, Polyclonal Antibody

 Also Known As   

Goat anti-FAPP2/PLEKHA8 Antibody

 Product Synonym Names    PLEKHA8; FAPP2; phosphoinositol 4-phosphate adaptor protein-2; MGC3358; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; PLEKHA8 antibody; FAPP2 antibody; phosphoinositol 4-phosphate adaptor protein-2 antibody; MGC3358 antibody; pleckstrin homology domain containing; family A (phosphoinositide binding specific) member 8 antibody; FAPP2 / PLEKHA8
 Product Gene Name   

anti-PLEKHA8 antibody

[Similar Products]
 Product Synonym Gene Name    PLEKHA8 [Similar Products]
 Antibody/Peptide Pairs    FAPP2 / PLEKHA8 peptide (MBS425227) is used for blocking the activity of FAPP2/PLEKHA8 antibody (MBS420752)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DIQTALRNPT ENT
 OMIM    608639
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DIQTALRNPTENT, from the C Terminus of the protein sequence according to NP_116028.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-PLEKHA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PLEKHA8 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-PLEKHA8 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Placenta shows strong staining of cytoplasm in the margins of villi. Recommended concentration, 2-4ug/ml.
Western Blot: Preliminary experiments gave no signal but low background in Human Kidney and Testis lysates at up to 1ug/ml.
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 Immunohistochemistry (IHC) of anti-PLEKHA8 antibody    (2.5ug/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-PLEKHA8 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PLEKHA8. It may not necessarily be applicable to this product.
 NCBI GI #    14249174
 NCBI GeneID    84725
 NCBI Accession #    NP_116028.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_032639.3 [Other Products]
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 UniProt Secondary Accession #    Q7Z5V8; Q9BU78; Q9H274; Q9H8Z7; B4DH00 [Other Products]
 UniProt Related Accession #    Q96JA3 [Other Products]
 Molecular Weight    49,462 Da
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 NCBI Official Full Name    pleckstrin homology domain-containing family A member 8 isoform 3
 NCBI Official Synonym Full Names    pleckstrin homology domain containing A8
 NCBI Official Symbol    PLEKHA8 [Similar Products]
 NCBI Official Synonym Symbols   
FAPP2
[Similar Products]
 NCBI Protein Information    pleckstrin homology domain-containing family A member 8
 UniProt Protein Name    Pleckstrin homology domain-containing family A member 8
 UniProt Synonym Protein Names   
Phosphatidylinositol-four-phosphate adapter protein 2; FAPP-2; Phosphoinositol 4-phosphate adapter protein 2; hFAPP2; Serologically defined breast cancer antigen NY-BR-86
 Protein Family    Pleckstrin homology domain-containing family
 UniProt Gene Name    PLEKHA8 [Similar Products]
 UniProt Synonym Gene Names    FAPP2; PH domain-containing family A member 8; FAPP-2; Phosphoinositol 4-phosphate adapter protein 2; hFAPP2 [Similar Products]
 UniProt Entry Name    PKHA8_HUMAN
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 UniProt Comments for PLEKHA8    PLEKHA8: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: membrane; trans-Golgi network

Molecular Function: glycolipid binding; glycolipid transporter activity

Biological Process: glycolipid transport; lipid transport; protein transport
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 Research Articles on PLEKHA8    1. Altogether, this study implies that hepatitis C virus coopts FAPP2 for virus genome replication via phosphatidylinositol 4-phosphate binding and glycosphingolipid transport to the hepatitis C virus replication complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-PLEKHA8 antibodyOrgans/Tissues associated with anti-PLEKHA8 antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >1 publications with PLEKHA8 and Chromosome Aberrations
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with PLEKHA8 and Kidney
 Heart Antibodies  >1 publications with PLEKHA8 and Heart
 Bone Antibodies  >1 publications with PLEKHA8 and Bone
 Brain Antibodies  >1 publications with PLEKHA8 and Brain
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