AAH52866.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 31 Observed MW: 33
NCBI Official Full Name
Fasl protein
NCBI Official Synonym Full Names
Fas ligand (TNF superfamily, member 6)
NCBI Official Synonym Symbols
gld; CD178; CD95L; Fas-L; Faslg; CD95-L; Tnfsf6; Tnlg1a; APT1LG1 [Similar Products]
NCBI Protein Information
tumor necrosis factor ligand superfamily member 6
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 6
UniProt Synonym Protein Names
CD95 ligand; CD95-L
UniProt Synonym Gene Names
Apt1lg1; Cd95l; Fasl; gld; Tnfsf6; CD95-L; Fas ligand; FasL; sFasL; APL; FasL ICD; SPA [Similar Products]
UniProt Entry Name
TNFL6_MOUSE
UniProt Comments for FAS-L
FasL: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Membrane protein, integral; Cytokine
Cellular Component: caveola; cell surface; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; external side of plasma membrane; extracellular region; extracellular space; integral to membrane; lipid raft; lysosome; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cytokine activity; death receptor binding; tumor necrosis factor receptor binding
Biological Process: apoptosis; caspase activation; cellular chloride ion homeostasis; endosomal lumen acidification; immune response; induction of apoptosis via death domain receptors; inflammatory cell apoptosis; negative regulation of angiogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of neuron apoptosis; regulation of transcription, DNA-dependent; retinal cell programmed cell death; transcription, DNA-dependent
Research Articles on FAS-L
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Products associated with anti-FAS-L antibody
Pathways associated with anti-FAS-L antibody
Diseases associated with anti-FAS-L antibody
Organs/Tissues associated with anti-FAS-L antibody
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