View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-FAS antibody :: Rabbit anti-Human, Mouse FAS Polyclonal Antibody Catalog # MBS2541758 Unit / Price 0.02 mL / $145 +1 FREE 8GB USB 0.06 mL / $185 +1 FREE 8GB USB 0.12 mL / $270 +1 FREE 8GB USB 0.2 mL / $395 +1 FREE 8GB USB 5x0.2 mL / $1,760 +2 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name FAS, Polyclonal Antibody Popular Item Full Product Name FAS Polyclonal Antibody Product Synonym Names ALPS1A; APO 1; Apo 1 antigen; APT1; CD95; FAS; FAS1; FASLG receptor; FASTM; TNFRSF6 Product Gene Name anti-FAS antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM M67454 mRNA Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse Purity/Purification Antigen Affinity Purification Concentration 4mg/ml (lot specific) Immunogen Recombinant human Tumor necrosis factor receptor superfamily member 6 protein Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Santa Cruz Alternative Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-74540 / sc-21730 / sc-8009 Preparation and Storage Store at -20 degree C. Avoid freeze/thaw cycles. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of anti-FAS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-FAS antibody Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form (40-55 kDa) of Fas is due to glycosylation. Product Categories/Family for anti-FAS antibody Cancer; Cell biology; Epigenetics Applications Tested/Suitable for anti-FAS antibody Western Blot (WB), Immunohistochemistry (IHC) Application Notes for anti-FAS antibody WB: 1:500-1:1000IHC: 1:50-1:100 Western Blot (WB) of anti-FAS antibody Western Blot analysis of Hela and Raji cells using FAS Polyclonal Antibody at dilution of 1:600 Immunohistochemistry (IHC) of anti-FAS antibody Immunohistochemistry of paraffin-embedded Mouse liver using FAS Polyclonal Antibody at dilution of 1:50 TOP NCBI/Uniprot data below describe general gene information for FAS. It may not necessarily be applicable to this product. NCBI GI # 526482526 NCBI GeneID 355 UniProt Secondary Accession # Q14292; Q14293; Q14294; Q14295; Q16652; Q5T9P1; Q5T9P2; Q5T9P3; Q6SSE9; A9UJX4; B6VNV4[Other Products] UniProt Related Accession # P25445[Other Products] Molecular Weight Calculated MW: 37kDObserved MW: 45kD TOP NCBI Official Full Name FAS, partial NCBI Official Synonym Full Names Fas cell surface death receptor NCBI Official Symbol FAS [Similar Products] NCBI Official Synonym Symbols APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6 [Similar Products] NCBI Protein Information tumor necrosis factor receptor superfamily member 6 UniProt Protein Name Tumor necrosis factor receptor superfamily member 6 UniProt Synonym Protein Names Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD_antigen: CD95 Protein Family Fascin UniProt Gene Name FAS [Similar Products] UniProt Synonym Gene Names APT1; FAS1; TNFRSF6 [Similar Products] UniProt Entry Name TNR6_HUMAN TOP NCBI Summary for FAS The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011] TOP UniProt Comments for FAS FAS: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokineChromosomal Location of Human Ortholog: 10q24.1Cellular Component: CD95 death-inducing signaling complex; cell surface; cytoplasm; integral to plasma membrane; lipid raft; neuron projection; nucleus; plasma membraneMolecular Function: identical protein binding; kinase binding; protein binding; signal transducer activity; tumor necrosis factor receptor activityBiological Process: apoptosis; brain development; caspase activation; immune response; induction of apoptosis via death domain receptors; inflammatory response; negative regulation of apoptosis; positive regulation of apoptosis; positive regulation of MAPKKK cascade; protein complex assembly; regulation of apoptosis; regulation of caspase activity; regulation of cell proliferation; response to lipopolysaccharide; signal transductionDisease: Autoimmune Lymphoproliferative Syndrome Research Articles on FAS 1. Genetic polymorphisms in the death pathway genes Fas and FasL were not associated with risk of developing esophageal carcinoma in a north Chinese population. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. 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TOP Products associated with anti-FAS antibody Reference Product PubMed Publications FASLG antibody >3728 publications with FAS and FASLG CASP8 antibody >3218 publications with FAS and CASP8 FADD antibody >2047 publications with FAS and FADD BID antibody >664 publications with FAS and BID CFLAR antibody >465 publications with FAS and CFLAR TRADD antibody >243 publications with FAS and TRADD PTPN13 antibody >80 publications with FAS and PTPN13 FAF1 antibody >76 publications with FAS and FAF1 CASP10 antibody >57 publications with FAS and CASP10 MAP3K5 antibody >19 publications with FAS and MAP3K5 Pathways associated with anti-FAS antibody Products by Pathway Pathway Diagram Adipogenesis Pathway antibodies Adipogenesis Pathway Diagram African Trypanosomiasis Pathway antibodies African Trypanosomiasis Pathway Diagram African Trypanosomiasis Pathway antibodies African Trypanosomiasis Pathway Diagram Allograft Rejection Pathway antibodies Allograft Rejection Pathway Diagram Allograft Rejection Pathway antibodies Allograft Rejection Pathway Diagram Allograft Rejection Pathway antibodies Allograft Rejection Pathway Diagram Alzheimer's Disease Pathway antibodies Alzheimer's Disease Pathway Diagram Alzheimer's Disease Pathway antibodies Alzheimer's Disease Pathway Diagram Alzheimers Disease Pathway antibodies Alzheimers Disease Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Diseases associated with anti-FAS antibody Disease Name Pubmed Publications Necrosis Antibodies >5264 publications with FAS and Necrosis Autoimmune Diseases Antibodies >2149 publications with FAS and Autoimmune Diseases Inflammation Antibodies >2042 publications with FAS and Inflammation Nervous System Diseases Antibodies >1754 publications with FAS and Nervous System Diseases Disease Models, Animal Antibodies >1656 publications with FAS and Disease Models, Animal Liver Diseases Antibodies >1654 publications with FAS and Liver Diseases Fatty Liver Antibodies >1220 publications with FAS and Fatty Liver Hematologic Diseases Antibodies >695 publications with FAS and Hematologic Diseases Heart Diseases Antibodies >602 publications with FAS and Heart Diseases Neoplasms, Experimental Antibodies >591 publications with FAS and Neoplasms, Experimental Organs/Tissues associated with anti-FAS antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >9965 publications with FAS and Blood Liver Antibodies >3333 publications with FAS and Liver Brain Antibodies >1874 publications with FAS and Brain Bone Antibodies >1563 publications with FAS and Bone Lung Antibodies >1330 publications with FAS and Lung Muscle Antibodies >1264 publications with FAS and Muscle Vascular Antibodies >1182 publications with FAS and Vascular Heart Antibodies >1035 publications with FAS and Heart Kidney Antibodies >938 publications with FAS and Kidney Bone Marrow Antibodies >887 publications with FAS and Bone Marrow TOP