NP_000498.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,842 Da
NCBI Official Full Name
fructose-1,6-bisphosphatase 1
NCBI Official Synonym Full Names
fructose-bisphosphatase 1
NCBI Official Synonym Symbols
NCBI Protein Information
fructose-1,6-bisphosphatase 1
UniProt Protein Name
Fructose-1,6-bisphosphatase 1
UniProt Synonym Protein Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase
UniProt Synonym Gene Names
UniProt Entry Name
F16P1_HUMAN
NCBI Summary for FBP1
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
UniProt Comments for FBP1
FBPase: a key enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate, a precursor to glucose 6-phosphate. A regulator of glucose synthesis from non-carbohydrates. Two paralogs of this enzyme exists in humans, FBP1 in the liver and FBP2 in muscle. While both forms are inhibited allosterically by AMP, NAD and Ca2+, the muscle form is about 100-fold more sensitive to AMP and NAD, and about 1000-fold more sensitive to inhibition by Ca2+. Forms homotetramers that are stabilized in the active state by divalent cations (Mg2+, Mn2+ , Co+2, or Zn2+). Deficiency of FBP1 leads to a disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.
Protein type: Phosphatase (non-protein); Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Mitochondrial
Chromosomal Location of Human Ortholog: 9q22.3
Cellular Component: cytoplasm; cytosol
Molecular Function: AMP binding; fructose-bisphosphatase activity; identical protein binding; metal ion binding; monosaccharide binding; protein binding
Biological Process: dephosphorylation; fructose 6-phosphate metabolic process; fructose metabolic process; gluconeogenesis; negative regulation of cell growth; negative regulation of glycolysis; negative regulation of Ras protein signal transduction; protein homotetramerization; regulation of gluconeogenesis
Disease: Fructose-1,6-bisphosphatase Deficiency
Research Articles on FBP1
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Products associated with anti-FBP1 antibody
Pathways associated with anti-FBP1 antibody
Diseases associated with anti-FBP1 antibody
Organs/Tissues associated with anti-FBP1 antibody
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