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anti-FNBP1 antibody :: Goat FBP17/FNBP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420283
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FBP17/FNBP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-FBP17/FNBP1 Antibody

 Product Synonym Names    FNBP1; FBP17; KIAA0554; formin binding protein 1; formin-binding protein 17; MGC126804; FNBP1 antibody; FBP17 antibody; KIAA0554 antibody; formin binding protein 1 antibody; formin-binding protein 17 antibody; MGC126804 antibody; FBP17 / FNBP1
 Product Gene Name   

anti-FNBP1 antibody

[Similar Products]
 Product Synonym Gene Name    FBP17 [Similar Products]
 Antibody/Peptide Pairs    FBP17 / FNBP1 peptide (MBS426462) is used for blocking the activity of FBP17/FNBP1 antibody (MBS420283)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KQLESSKRRF ERDC
 OMIM    606191
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence KQLESSKRRFERDC, from the internal region of the protein sequence according to NP_055848.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-FNBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FNBP1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-FNBP1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 70kDa band observed in human testis lysates (calculated MW of 71.3kDa according to NP_055848.1). Recommended concentration: 0.25-2ug/ml.
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 Western Blot (WB) of anti-FNBP1 antibody    Staining (0.25ug/ml) of human testis lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-FNBP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FNBP1. It may not necessarily be applicable to this product.
 NCBI GI #    38524622
 NCBI GeneID    23048
 NCBI Accession #    NP_055848.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_015033.2 [Other Products]
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 UniProt Secondary Accession #    O60301; Q3MIN8; Q5TC87; Q5TC88; Q6P658; Q7LGG2; Q9H8H8; Q9NWD1; B7ZL12; E9PGQ4 [Other Products]
 UniProt Related Accession #    Q96RU3 [Other Products]
 Molecular Weight    70,752 Da
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 NCBI Official Full Name    formin-binding protein 1
 NCBI Official Synonym Full Names    formin binding protein 1
 NCBI Official Symbol    FNBP1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    formin-binding protein 1
 UniProt Protein Name    Formin-binding protein 1
 UniProt Synonym Protein Names   
Formin-binding protein 17; hFBP17
 Protein Family    Formin-binding protein
 UniProt Gene Name    FNBP1 [Similar Products]
 UniProt Synonym Gene Names    FBP17; KIAA0554; hFBP17 [Similar Products]
 UniProt Entry Name    FNBP1_HUMAN
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 NCBI Summary for FNBP1    The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FNBP1    FNBP1: May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation. Belongs to the FNBP1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Vesicle

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cell cortex; coated pit; cytoplasmic membrane-bound vesicle; cytoskeleton; lysosome; plasma membrane; trans-Golgi network

Molecular Function: ARF guanyl-nucleotide exchange factor activity; identical protein binding; lipid binding; protein binding

Biological Process: endocytosis; positive regulation of GTPase activity; vesicle-mediated transport
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 Research Articles on FNBP1    1. FBP17 is the local activator of actin polymerization that is inhibited by PM tension in the feedback loop that regulates cell migration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FNBP1 antibodyDiseases associated with anti-FNBP1 antibody
 Reference Product  PubMed Publications
 SRC antibody  >18 publications with FNBP1 and SRC
 CDC42 antibody  >7 publications with FNBP1 and CDC42
 C9orf78 antibody  >1 publications with FNBP1 and C9orf78
 FASLG antibody  >1 publications with FNBP1 and FASLG
 SNX2 antibody  >1 publications with FNBP1 and SNX2
 WASL antibody  >1 publications with FNBP1 and WASL
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with FNBP1 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >1 publications with FNBP1 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >1 publications with FNBP1 and Kidney Diseases
 Inflammation Antibodies  >1 publications with FNBP1 and Inflammation
Organs/Tissues associated with anti-FNBP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with FNBP1 and Brain
 Testis Antibodies  >3 publications with FNBP1 and Testis
 Kidney Antibodies  >3 publications with FNBP1 and Kidney
 Blood Antibodies  >2 publications with FNBP1 and Blood
 Eye Antibodies  >1 publications with FNBP1 and Eye
 Embryonic Tissue Antibodies  >1 publications with FNBP1 and Embryonic Tissue
 Vascular Antibodies  >1 publications with FNBP1 and Vascular
 Bone Marrow Antibodies  >1 publications with FNBP1 and Bone Marrow
 Bladder Antibodies  >1 publications with FNBP1 and Bladder
 Esophagus Antibodies  >1 publications with FNBP1 and Esophagus
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