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anti-FBXL3 antibody :: Goat FBXL3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420338
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FBXL3, Polyclonal Antibody

 Also Known As   

Goat anti-FBXL3 Antibody

 Product Synonym Names    FBXL3; F-box and leucine-rich repeat protein 3; FBL3; FBL3A; FBXL3A; F-box and leucine-rich repeat protein 3A; F-box protein Fbl3a; FBXL3 antibody; F-box and leucine-rich repeat protein 3 antibody; FBL3 antibody; FBL3A antibody; FBXL3A antibody; F-box and leucine-rich repeat protein 3A antibody; F-box protein Fbl3a antibody
 Product Gene Name   

anti-FBXL3 antibody

[Similar Products]
 Antibody/Peptide Pairs    FBXL3 peptide (MBS426579) is used for blocking the activity of FBXL3 antibody (MBS420338)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KRGGRDSDRN SSEE
 OMIM    605653
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence KRGGRDSDRNSSEE-C, from the N Terminus of the protein sequence according to NP_036290.1.
 Epitope    N Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-FBXL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FBXL3 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-FBXL3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 50-55kDa band observed in Human Adipose lysates (calculated MW of 48.7kDa according to NP_036290.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-FBXL3 antibody    (1ug/ml) staining of Human Adipose lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-FBXL3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FBXL3. It may not necessarily be applicable to this product.
 NCBI GI #    16306584
 NCBI GeneID    26224
 NCBI Accession #    NP_036290.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012158.2 [Other Products]
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 UniProt Secondary Accession #    Q9P122; B2RB04 [Other Products]
 UniProt Related Accession #    Q9UKT7 [Other Products]
 Molecular Weight    48,707 Da
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 NCBI Official Full Name    F-box/LRR-repeat protein 3
 NCBI Official Synonym Full Names    F-box and leucine-rich repeat protein 3
 NCBI Official Symbol    FBXL3 [Similar Products]
 NCBI Official Synonym Symbols   
FBL3; FBL3A; FBXL3A
[Similar Products]
 NCBI Protein Information    F-box/LRR-repeat protein 3
 UniProt Protein Name    F-box/LRR-repeat protein 3
 UniProt Synonym Protein Names   
F-box and leucine-rich repeat protein 3A; F-box/LRR-repeat protein 3A
 UniProt Gene Name    FBXL3 [Similar Products]
 UniProt Synonym Gene Names    FBL3A; FBXL3A [Similar Products]
 UniProt Entry Name    FBXL3_HUMAN
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 NCBI Summary for FBXL3    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FBXL3    FBXL3: Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 13q22

Cellular Component: cytosol; nucleus; SCF ubiquitin ligase complex; ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: entrainment of circadian clock by photoperiod; protein destabilization; protein ubiquitination; regulation of circadian rhythm; rhythmic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
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 Research Articles on FBXL3    1. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-FBXL3 antibodyDiseases associated with anti-FBXL3 antibody
 Products by Pathway  Pathway Diagram
 Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies  Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Protein Folding Pathway antibodies  Protein Folding Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with FBXL3 and Inflammation
 Necrosis Antibodies  >1 publications with FBXL3 and Necrosis
Organs/Tissues associated with anti-FBXL3 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with FBXL3 and Liver
 Brain Antibodies  >5 publications with FBXL3 and Brain
 Heart Antibodies  >3 publications with FBXL3 and Heart
 Lung Antibodies  >2 publications with FBXL3 and Lung
 Thyroid Antibodies  >1 publications with FBXL3 and Thyroid
 Eye Antibodies  >1 publications with FBXL3 and Eye
 Intestine Antibodies  >1 publications with FBXL3 and Intestine
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