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anti-FBXO32 antibody :: Goat FBXO32 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421930
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FBXO32, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-FBXO32 Antibody

 Product Synonym Names    FBXO32; F-box protein 32; FLJ32424; Fbx32; MAFbx; MGC33610; F-box only protein 32; atrogin 1; muscle atrophy F-box protein; FBXO32 antibody; F-box protein 32 antibody; FLJ32424 antibody; Fbx32 antibody; MAFbx antibody; MGC33610 antibody; F-box only protein 32 antibody; atrogin 1 antibody; muscle atrophy F-box protein antibody
 Product Gene Name   

anti-FBXO32 antibody

[Similar Products]
 Antibody/Peptide Pairs    FBXO32 peptide (MBS426616) is used for blocking the activity of FBXO32 antibody (MBS421930)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    NSKTKTQYFH QEK
 OMIM    606604
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Cow, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-NSKTKTQYFHQEK, from the internal region of the protein sequence according to NP_478136.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize reported isoform 1 (NP_478136.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-FBXO32 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FBXO32 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-FBXO32 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: approx. 40kDa band observed in Human and Mouse Skeletal Muscle lysates (calculated MW of 41.6kDa according to Human NP_478136.1 and of 41.5kDa according to Mouse NP_080622.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-FBXO32 antibody    (1ug/ml) staining of Human Skeletal Muscle lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-FBXO32 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FBXO32. It may not necessarily be applicable to this product.
 NCBI GI #    17158037
 NCBI GeneID    114907
 NCBI Accession #    NP_478136.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_058229.3 [Other Products]
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 UniProt Secondary Accession #    A4KYM0 [Other Products]
 UniProt Related Accession #    Q969P5 [Other Products]
 Molecular Weight    30,804 Da
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 NCBI Official Full Name    F-box only protein 32 isoform 1
 NCBI Official Synonym Full Names    F-box protein 32
 NCBI Official Symbol    FBXO32 [Similar Products]
 NCBI Official Synonym Symbols   
Fbx32; MAFbx
[Similar Products]
 NCBI Protein Information    F-box only protein 32
 UniProt Protein Name    F-box only protein 32
 UniProt Synonym Protein Names   
Atrogin-1; Muscle atrophy F-box protein; MAFbx
 Protein Family    F-box only protein
 UniProt Gene Name    FBXO32 [Similar Products]
 UniProt Synonym Gene Names    MAFbx [Similar Products]
 UniProt Entry Name    FBX32_HUMAN
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 NCBI Summary for FBXO32    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
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 UniProt Comments for FBXO32    FBXO32: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 8q24.13

Cellular Component: cytoplasm; nucleoplasm; nucleus; SCF ubiquitin ligase complex; Z disc

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: protein ubiquitination; response to denervation involved in regulation of muscle adaptation; ubiquitin-dependent protein catabolic process
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 Research Articles on FBXO32    1. Our data suggest that FBXO32 is a candidate gene for recessive familial dilated cardiomyopathy. Acting as a cardiac ubiquitin ligase, mutated FBXO32 could perturb the degradation of target proteins in the ubiquitin proteasome system.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FBXO32 antibodyPathways associated with anti-FBXO32 antibody
 Reference Product  PubMed Publications
 TRIM63 antibody  >269 publications with FBXO32 and TRIM63
 FOXO1 antibody  >59 publications with FBXO32 and FOXO1
 FOXO3 antibody  >52 publications with FBXO32 and FOXO3
 MYOD1 antibody  >18 publications with FBXO32 and MYOD1
 MYOG antibody  >8 publications with FBXO32 and MYOG
 SKP1 antibody  >5 publications with FBXO32 and SKP1
 EIF3F antibody  >3 publications with FBXO32 and EIF3F
 SERPINB5 antibody  >2 publications with FBXO32 and SERPINB5
 KHDRBS3 antibody  >1 publications with FBXO32 and KHDRBS3
 Products by Pathway  Pathway Diagram
 FoxO Family Signaling Pathway antibodies  FoxO Family Signaling Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
Diseases associated with anti-FBXO32 antibodyOrgans/Tissues associated with anti-FBXO32 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >219 publications with FBXO32 and Nervous System Diseases
 Muscular Atrophy Antibodies  >206 publications with FBXO32 and Muscular Atrophy
 Disease Models, Animal Antibodies  >67 publications with FBXO32 and Disease Models, Animal
 Hypertrophy Antibodies  >62 publications with FBXO32 and Hypertrophy
 Weight Loss Antibodies  >56 publications with FBXO32 and Weight Loss
 Necrosis Antibodies  >48 publications with FBXO32 and Necrosis
 Inflammation Antibodies  >45 publications with FBXO32 and Inflammation
 Cardiovascular Diseases Antibodies  >44 publications with FBXO32 and Cardiovascular Diseases
 Heart Diseases Antibodies  >41 publications with FBXO32 and Heart Diseases
 Lung Diseases Antibodies  >23 publications with FBXO32 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >434 publications with FBXO32 and Muscle
 Heart Antibodies  >58 publications with FBXO32 and Heart
 Nerve Antibodies  >46 publications with FBXO32 and Nerve
 Lung Antibodies  >20 publications with FBXO32 and Lung
 Vascular Antibodies  >15 publications with FBXO32 and Vascular
 Liver Antibodies  >15 publications with FBXO32 and Liver
 Kidney Antibodies  >8 publications with FBXO32 and Kidney
 Bone Antibodies  >7 publications with FBXO32 and Bone
 Brain Antibodies  >7 publications with FBXO32 and Brain
 Stomach Antibodies  >5 publications with FBXO32 and Stomach
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