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anti-FCGR3A antibody :: Rabbit FCGR3A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2525376
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FCGR3A, Polyclonal Antibody

 Also Known As   

FCGR3A Polyclonal Antibody

 Product Synonym Names    CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA
 Product Gene Name   

anti-FCGR3A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146740
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    2.7mg/mL (lot specific)
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 Immunogen    Recombinant protein of human FCGR3A
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-FCGR3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-FCGR3A antibody

   This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage.
 Applications Tested/Suitable for anti-FCGR3A antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-FCGR3A antibody    IHC: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-FCGR3A antibody    Immunohistochemistry of Human brain using FCGR3A Polyclonal Antibody at dilution of 1:60
anti-FCGR3A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FCGR3A. It may not necessarily be applicable to this product.
 NCBI GI #    21708067
 NCBI GeneID    2214
 NCBI Accession #    AAH33678.1 [Other Products]
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 UniProt Secondary Accession #    Q53FJ0; Q53FL6; Q5EBR4; Q65ZM6; Q6PIJ0; A2N6W9 [Other Products]
 UniProt Related Accession #    P08637 [Other Products]
 Molecular Weight    29,089 Da
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 NCBI Official Full Name    FCGR3A protein
 NCBI Official Synonym Full Names    Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
 NCBI Official Symbol    FCGR3A [Similar Products]
 NCBI Official Synonym Symbols   
CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA
[Similar Products]
 NCBI Protein Information    low affinity immunoglobulin gamma Fc region receptor III-A; CD16a antigen; Fc fragment of IgG, low affinity III, receptor for (CD16); Fc gamma receptor III-A; Fc-gamma RIII-alpha; Fc-gamma RIIIa; Fc-gamma receptor III-2 (CD 16); Fc-gamma receptor IIIb (CD16); FcgammaRIIIA; fc-gamma RIII; igG Fc receptor III-2; immunoglobulin G Fc receptor III; neutrophil-specific antigen NA
 UniProt Protein Name    Low affinity immunoglobulin gamma Fc region receptor III-A
 UniProt Synonym Protein Names   
CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: CD16a
 Protein Family    Low affinity immunoglobulin gamma Fc region receptor
 UniProt Gene Name    FCGR3A [Similar Products]
 UniProt Synonym Gene Names    CD16A; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa [Similar Products]
 UniProt Entry Name    FCG3A_HUMAN
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 NCBI Summary for FCGR3A    This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FCGR3A    FCGR3A: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: IgG binding

Biological Process: regulation of immune response; innate immune response; immune response

Disease: Immunodeficiency 20
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 Research Articles on FCGR3A    1. These results suggest that carrying a FCRG3A F allele does not negatively affect rituximab therapy in immunosuppressed patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FCGR3A antibodyPathways associated with anti-FCGR3A antibody
 Reference Product  PubMed Publications
 SYK antibody  >2 publications with FCGR3A and SYK
 TYROBP antibody  >1 publications with FCGR3A and TYROBP
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
Diseases associated with anti-FCGR3A antibodyOrgans/Tissues associated with anti-FCGR3A antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >28 publications with FCGR3A and Necrosis
 Intestinal Diseases Antibodies  >27 publications with FCGR3A and Intestinal Diseases
 Lupus Erythematosus, Systemic Antibodies  >25 publications with FCGR3A and Lupus Erythematosus, Systemic
 Cardiovascular Diseases Antibodies  >23 publications with FCGR3A and Cardiovascular Diseases
 Inflammation Antibodies  >17 publications with FCGR3A and Inflammation
 Leukemia Antibodies  >14 publications with FCGR3A and Leukemia
 Breast Neoplasms Antibodies  >13 publications with FCGR3A and Breast Neoplasms
 Kidney Diseases Antibodies  >12 publications with FCGR3A and Kidney Diseases
 Neoplasms, Experimental Antibodies  >10 publications with FCGR3A and Neoplasms, Experimental
 Carcinoma Antibodies  >8 publications with FCGR3A and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >156 publications with FCGR3A and Blood
 Kidney Antibodies  >8 publications with FCGR3A and Kidney
 Ovary Antibodies  >6 publications with FCGR3A and Ovary
 Lung Antibodies  >5 publications with FCGR3A and Lung
 Liver Antibodies  >4 publications with FCGR3A and Liver
 Brain Antibodies  >3 publications with FCGR3A and Brain
 Prostate Antibodies  >1 publications with FCGR3A and Prostate
 Intestine Antibodies  >1 publications with FCGR3A and Intestine
 Spleen Antibodies  >1 publications with FCGR3A and Spleen
 Connective Tissue Antibodies  >1 publications with FCGR3A and Connective Tissue
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