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anti-FCRL4 antibody :: Rabbit anti-Human FCRL4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6000748
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FCRL4, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-Human FCRL4, CT (FCRL4, FCRH4, IFGP2, IRTA1, Fc receptor-like protein 4, Fc receptor homolog 4, IFGP family protein 2, Immune receptor translocation-associated protein 1, CD307d)

 Product Synonym Names    Anti -FCRL4, CT (FCRL4, FCRH4, IFGP2, IRTA1, Fc receptor-like protein 4, Fc receptor homolog 4, IFGP family protein 2, Immune receptor translocation-associated protein 1, CD307d)
 Product Gene Name   

anti-FCRL4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (157543539..157567870, complement). Location: 1q21
 OMIM    605876
 3D Structure    ModBase 3D Structure for Q96PJ5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes Human FCRL4
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
 Concentration    0.5 mg/ml (lot specific)
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 Immunogen    KLH conjugated synthetic peptide mapping to a fragment of residues within amino acids aa480-507 in the C-terminal region of human FCRL4.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-FCRL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FCRL4 antibody

   This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma.
 Product Categories/Family for anti-FCRL4 antibody    Antibodies; Abs to CD Markers
 Applications Tested/Suitable for anti-FCRL4 antibody   

ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-FCRL4 antibody    Dilution:
Western Blot: 1:2000
Flow Cytometry: 1:10-50
Optimal dilutions to be determined by the researcher
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 Western Blot of anti-FCRL4 antibody    Western Blot analysis in Ramos cell line lysates (35ug/lane). FCRL4 (arrow) was detected using the purified Pab
anti-FCRL4 antibody Western Blot (WB) image
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 Flow Cytometric of anti-FCRL4 antibody    Flow Cytometric analysis of Ramos cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-FCRL4 antibody Flow Cytometric image
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NCBI/Uniprot data below describe general gene information for FCRL4. It may not necessarily be applicable to this product.
 NCBI GI #    14550416
 NCBI GeneID    83417
 NCBI Accession #    NP_112572.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031282.2 [Other Products]
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 UniProt Primary Accession #    Q96PJ5 [Other Products]
 UniProt Secondary Accession #    Q96PJ3; Q96RE0 [Other Products]
 UniProt Related Accession #    Q96PJ5 [Other Products]
 Molecular Weight    57,224 Da [Similar Products]
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 NCBI Official Full Name    Fc receptor-like protein 4
 NCBI Official Synonym Full Names    Fc receptor-like 4
 NCBI Official Symbol    FCRL4 [Similar Products]
 NCBI Official Synonym Symbols   
FCRH4; IGFP2; IRTA1; CD307d
[Similar Products]
 NCBI Protein Information    Fc receptor-like protein 4; hIFGP2; fcR-like protein 4; IFGP family protein 2; fc receptor homolog 4; immunoglobulin superfamily Fc receptor, gp42; immune receptor translocation-associated protein 1; immunoglobulin superfamily receptor translocation associated 1
 UniProt Protein Name    Fc receptor-like protein 4
 UniProt Synonym Protein Names   
Fc receptor homolog 4; FcRH4; IFGP family protein 2; hIFGP2; Immune receptor translocation-associated protein 1
 Protein Family    Fc receptor-like protein
 UniProt Gene Name    FCRL4 [Similar Products]
 UniProt Synonym Gene Names    FCRH4; IFGP2; IRTA1; FcR-like protein 4; FcRL4; FcRH4; hIFGP2 [Similar Products]
 UniProt Entry Name    FCRL4_HUMAN
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 NCBI Summary for FCRL4    This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
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 UniProt Comments for FCRL4    FCRL4: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: immune system process
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 Research Articles on FCRL4    1. The cytological features, growth pattern and IRTA1 positivity in nodal marginal zone lymphomas suggest they may derive from IRTA1(+) perifollicular B cells or monocytoid B cells detectable in reactive lymph nodes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FCRL4 antibodyDiseases associated with anti-FCRL4 antibody
 Reference Product  PubMed Publications
 CD27 antibody  >8 publications with FCRL4 and CD27
 Disease Name  Pubmed Publications
 Immunologic Deficiency Syndromes Antibodies  >3 publications with FCRL4 and Immunologic Deficiency Syndromes
 Cell Transformation, Neoplastic Antibodies  >2 publications with FCRL4 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >1 publications with FCRL4 and Necrosis
 Inflammation Antibodies  >1 publications with FCRL4 and Inflammation
Organs/Tissues associated with anti-FCRL4 antibody
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >3 publications with FCRL4 and Lymph Node
 Mixed Antibodies  >1 publications with FCRL4 and Mixed
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