NP_112572.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Fc receptor-like protein 4
NCBI Official Synonym Full Names
Fc receptor-like 4
NCBI Protein Information
Fc receptor-like protein 4; hIFGP2; fcR-like protein 4; IFGP family protein 2; fc receptor homolog 4; immunoglobulin superfamily Fc receptor, gp42; immune receptor translocation-associated protein 1; immunoglobulin superfamily receptor translocation associated 1
UniProt Protein Name
Fc receptor-like protein 4
UniProt Synonym Protein Names
Fc receptor homolog 4; FcRH4; IFGP family protein 2; hIFGP2; Immune receptor translocation-associated protein 1
UniProt Synonym Gene Names
FCRH4; IFGP2; IRTA1; FcR-like protein 4; FcRL4; FcRH4; hIFGP2 [Similar Products]
UniProt Entry Name
FCRL4_HUMAN
NCBI Summary for FCRL4
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
UniProt Comments for FCRL4
FCRL4: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: plasma membrane; integral to membrane
Molecular Function: protein binding
Biological Process: immune system process
Research Articles on FCRL4
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Products associated with anti-FCRL4 antibody
Diseases associated with anti-FCRL4 antibody
Organs/Tissues associated with anti-FCRL4 antibody
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