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anti-WDFY1 antibody :: Goat FENS1/WDFY1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420558
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FENS1/WDFY1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-FENS1/WDFY1 Antibody

 Product Synonym Names    WDFY1; WDF1; FENS-1; KIAA1435; WD repeat and FYVE domain containing 1; WD40 and FYVE domain containing 1; phosphoinositide-binding protein SR1; ZFYVE17; WDFY1 antibody; WDF1 antibody; FENS-1 antibody; KIAA1435 antibody; WD repeat and FYVE domain containing 1 antibody; WD40 and FYVE domain containing 1 antibody; phosphoinositide-binding protein SR1 antibody; ZFYVE17 antibody; FENS1 / WDFY1
 Product Gene Name   

anti-WDFY1 antibody

[Similar Products]
 Product Synonym Gene Name    FENS1 [Similar Products]
 Antibody/Peptide Pairs    FENS1 / WDFY1 peptide (MBS426018) is used for blocking the activity of FENS1/WDFY1 antibody (MBS420558)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    VVGCSLATGF SPH
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence VVGCSLATGFSPH, from the C Terminus of the protein sequence according to NP_065881.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise both reported isoforms (as represented by NP_065881 and NP_848127)
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-WDFY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-WDFY1 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-WDFY1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Liver shows vesicular staining in the cytoplasm of hepatoicytes. Recommended concentration, 4-6ug/ml.
Western Blot: Preliminary experiments gave no signal but low background in Human Liver and HepG2 lysates at up to 1ug/ml.
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 Immunohistochemistry (IHC) of anti-WDFY1 antibody    (4ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
anti-WDFY1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for WDFY1. It may not necessarily be applicable to this product.
 NCBI GI #    18482373
 NCBI GeneID    57590
 NCBI Accession #    NP_065881.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020830.4 [Other Products]
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 UniProt Secondary Accession #    Q53S17; Q9H9D5; Q9P2B3 [Other Products]
 UniProt Related Accession #    Q8IWB7 [Other Products]
 Molecular Weight    46,324 Da
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 NCBI Official Full Name    WD repeat and FYVE domain-containing protein 1
 NCBI Official Synonym Full Names    WD repeat and FYVE domain containing 1
 NCBI Official Symbol    WDFY1 [Similar Products]
 NCBI Official Synonym Symbols   
WDF1; FENS-1; ZFYVE17
[Similar Products]
 NCBI Protein Information    WD repeat and FYVE domain-containing protein 1
 UniProt Protein Name    WD repeat and FYVE domain-containing protein 1
 UniProt Synonym Protein Names   
FENS-1; Phosphoinositide-binding protein 1; WD40- and FYVE domain-containing protein 1; Zinc finger FYVE domain-containing protein 17
 Protein Family    WD repeat and FYVE domain-containing protein
 UniProt Gene Name    WDFY1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1435; WDF1; ZFYVE17 [Similar Products]
 UniProt Entry Name    WDFY1_HUMAN
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 NCBI Summary for WDFY1    The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]
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 UniProt Comments for WDFY1    WDFY1: Binds PtdIns3P in vitro with high specificity over other phosphoinositides.

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: cytosol; early endosome; nucleus

Molecular Function: phosphatidylinositol binding; protein binding; zinc ion binding

Biological Process: positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway
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 Research Articles on WDFY1    1. WDFY1 mediates TLR3/TLR4 signaling by recruiting TRIF.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-WDFY1 antibodyOrgans/Tissues associated with anti-WDFY1 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with WDFY1 and Disease Models, Animal
 Atrophy Antibodies  >2 publications with WDFY1 and Atrophy
 Fetal Death Antibodies  >1 publications with WDFY1 and Fetal Death
 Fibrosis Antibodies  >1 publications with WDFY1 and Fibrosis
 Poisoning Antibodies  >1 publications with WDFY1 and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with WDFY1 and Brain
 Pancreas Antibodies  >1 publications with WDFY1 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with WDFY1 and Embryonic Tissue
 Vascular Antibodies  >1 publications with WDFY1 and Vascular
 Prostate Antibodies  >1 publications with WDFY1 and Prostate
 Blood Antibodies  >1 publications with WDFY1 and Blood
 Placenta Antibodies  >1 publications with WDFY1 and Placenta
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