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anti-FES antibody :: Rabbit FES Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS177028
Testing Data
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FES, Polyclonal Antibody

 Also Known As   

Anti-FES antibody

 Product Synonym Names    Tyrosine-protein kinase Fes/Fps; feline sarcoma oncogene; c-fes/fps protein antibody; cFES antibody; feline sarcoma(Snyder-Theilen) viral(v-fes)/Fujinami antibody; Feline sarcoma oncogene antibody; fes antibody; FES_HUMAN antibody; FPS antibody; Oncogene FES antibody; Oncogene FES feline sarcoma virus antibody; Proto oncogene tyrosine protein kinase Fes/Fps antibody; Proto-oncogene c-Fes antibody; Proto-oncogene c-Fps antibody; proto-oncogene tyrosine-protein kinase Fes/Fps antibody; Tyrosine-protein kinase Fes/Fps antibody
 Product Gene Name   

anti-FES antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    190030
 3D Structure    ModBase 3D Structure for P07332
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human FES (644-663aa FLTFLRTEGARLRVKTLLQM), identical to the related mouse and rat sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FES antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-FES antibody

   Description: Rabbit IgG polyclonal antibody for Tyrosine-protein kinase Fes/Fps(FES) detection. Tested with WB in Human, Mouse, Rat.
Background: FES(feline sarcoma oncogene) is an enzyme that in humans is encoded by the FES gene, also known as Proto-oncogene tyrosine-protein kinase Fes/Fps, Feline sarcoma/Fujinami avian sarcoma oncogene homolog, Proto-oncogene c-Fes, Proto-oncogene c-Fps, p93c-fes c-fes/fps protein, FPS, Oncogene FES, feline sarcoma virus, FPS. This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. Non-onc intervening sequences were present in the human counterpart. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia, but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.
 Applications Tested/Suitable for anti-FES antibody   

Western Blot (WB)

 Application Notes for anti-FES antibody    Wester Blot:
Concentration: 0.1-0.5ug/ml
Tested Species: Hu
Predicted Species: Ms, Rat
Antigen Retrieval: n/a

Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested.
Optimal dilutions should be determine by end users.
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 Testing Data of anti-FES antibody    anti-FES antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for FES. It may not necessarily be applicable to this product.
 NCBI GI #    115502390
 NCBI GeneID    2242
 NCBI Accession #    P07332.3 [Other Products]
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 UniProt Primary Accession #    P07332 [Other Products]
 UniProt Secondary Accession #    Q2VXS7; Q2VXS8; Q2VXT0; Q6GTU5; B2R6E6; B4DUD0; E9PC94; E9PC95 [Other Products]
 UniProt Related Accession #    P07332 [Other Products]
 Molecular Weight    85,466 Da
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 NCBI Official Full Name    Tyrosine-protein kinase Fes/Fps
 NCBI Official Synonym Full Names    FES proto-oncogene, tyrosine kinase
 NCBI Official Symbol    FES [Similar Products]
 NCBI Official Synonym Symbols   
FPS
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase Fes/Fps; p93c-fes; proto-oncogene c-Fes; proto-oncogene c-Fps; feline sarcoma oncogene; Oncogene FES, feline sarcoma virus; proto-oncogene tyrosine-protein kinase Fes/Fps; feline sarcoma/Fujinami avian sarcoma oncogene homolog; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
 UniProt Protein Name    Tyrosine-protein kinase Fes/Fps
 UniProt Synonym Protein Names   
Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fes; Proto-oncogene c-Fps; p93c-fes
 Protein Family    Festuclavine dehydrogenase
 UniProt Gene Name    FES [Similar Products]
 UniProt Synonym Gene Names    FPS [Similar Products]
 UniProt Entry Name    FES_HUMAN
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 NCBI Summary for FES    This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
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 UniProt Comments for FES    Fes: a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Oncoprotein; Tumor suppressor; TK group; Fer family

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: microtubule cytoskeleton; Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasmic membrane-bound vesicle; cytoplasm; cytoplasmic vesicle; cytosol

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; ATP binding

Biological Process: regulation of mast cell degranulation; epidermal growth factor receptor signaling pathway; regulation of cell adhesion; axon guidance; cell migration; peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; protein amino acid autophosphorylation; multicellular organismal development; positive regulation of microtubule polymerization; chemotaxis; protein amino acid phosphorylation; regulation of cell proliferation; cell proliferation; regulation of cell shape; regulation of cell differentiation; innate immune response
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 Research Articles on FES    1. analysis of the JAK-Fes-phospholipase D signaling pathway that is enhanced in highly proliferative breast cancer cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FES antibodyPathways associated with anti-FES antibody
 Reference Product  PubMed Publications
 STAT3 antibody  >24 publications with FES and STAT3
 BCR antibody  >24 publications with FES and BCR
 JAK3 antibody  >7 publications with FES and JAK3
 JAK1 antibody  >6 publications with FES and JAK1
 IRS2 antibody  >3 publications with FES and IRS2
 PLXNA1 antibody  >2 publications with FES and PLXNA1
 Products by Pathway  Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-4 Signaling Pathway antibodies  IL-4 Signaling Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
Diseases associated with anti-FES antibodyOrgans/Tissues associated with anti-FES antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >69 publications with FES and Breast Neoplasms
 Congenital Abnormalities Antibodies  >48 publications with FES and Congenital Abnormalities
 Adenocarcinoma Antibodies  >40 publications with FES and Adenocarcinoma
 Inflammation Antibodies  >38 publications with FES and Inflammation
 Neoplasms, Experimental Antibodies  >36 publications with FES and Neoplasms, Experimental
 Necrosis Antibodies  >30 publications with FES and Necrosis
 Edema Antibodies  >28 publications with FES and Edema
 Neoplasm Metastasis Antibodies  >23 publications with FES and Neoplasm Metastasis
 Abnormalities, Multiple Antibodies  >21 publications with FES and Abnormalities, Multiple
 Skin Neoplasms Antibodies  >17 publications with FES and Skin Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >828 publications with FES and Muscle
 Blood Antibodies  >377 publications with FES and Blood
 Bone Antibodies  >305 publications with FES and Bone
 Nerve Antibodies  >275 publications with FES and Nerve
 Brain Antibodies  >273 publications with FES and Brain
 Vascular Antibodies  >125 publications with FES and Vascular
 Lung Antibodies  >97 publications with FES and Lung
 Skin Antibodies  >83 publications with FES and Skin
 Liver Antibodies  >76 publications with FES and Liver
 Bone Marrow Antibodies  >69 publications with FES and Bone Marrow
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