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anti-FFAR1 antibody :: Rabbit FFAR1 / GPR40 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS243557
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FFAR1 / GPR40, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human FFAR1 / GPR40

 Product Synonym Names    Anti-FFAR1 / GPR40 Antibody (C-Terminus) IHC-plus; FFAR1; FFAR; FFA1R; G protein-coupled receptor 40; GPCR40; GPR40; Free fatty acid receptor; Free fatty acid receptor 1; G-protein coupled receptor 40; Human FFAR1; GPR40
 Product Gene Name   

anti-FFAR1 antibody

[Similar Products]
 Product Synonym Gene Name    GPR40 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603820
 3D Structure    ModBase 3D Structure for O14842
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gorilla, Human, Monkey
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 Specificity    Human GPR40. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 18 amino acid peptide from C-terminus of human GPR40. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Rabbit (89%).
 Immunogen Type    Synthetic peptide
 Immunogen    FFAR1 / GPR40 antibody was raised against synthetic 18 amino acid peptide from C-terminus of human GPR40. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Rabbit (89%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-FFAR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FFAR1 antibody

   GPR40 is classified as a Carboxylic Acid GPCR that may be associated with glucose and insulin secretion to regulate pancreatic islet function. Additional roles in neurological functions have also been speculated.
 Product Categories/Family for anti-FFAR1 antibody    Family: GPCR
Subfamily: Carboxylic Acid
 Applications Tested/Suitable for anti-FFAR1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-FFAR1 antibody    IHC-P (9 - 18 ug/ml), WB
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 Immunohistochemistry (IHC) of anti-FFAR1 antibody    Anti-GPR40 antibody IHC of human brain, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-FFAR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FFAR1 antibody    Anti-FFAR1 / GPR40 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-FFAR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FFAR1 antibody    Anti-FFAR1 / GPR40 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-FFAR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FFAR1. It may not necessarily be applicable to this product.
 NCBI GI #    4885327
 NCBI GeneID    2864
 NCBI Accession #    NP_005294.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005303.2 [Other Products]
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 UniProt Primary Accession #    O14842 [Other Products]
 UniProt Secondary Accession #    Q0VAS2; Q4VBL4 [Other Products]
 UniProt Related Accession #    O14842 [Other Products]
 Molecular Weight    31,457 Da
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 NCBI Official Full Name    free fatty acid receptor 1
 NCBI Official Synonym Full Names    free fatty acid receptor 1
 NCBI Official Symbol    FFAR1 [Similar Products]
 NCBI Official Synonym Symbols   
FFA1R; GPR40; GPCR40
[Similar Products]
 NCBI Protein Information    free fatty acid receptor 1; G protein-coupled receptor 40; G-protein coupled receptor 40
 UniProt Protein Name    Free fatty acid receptor 1
 UniProt Synonym Protein Names   
G-protein coupled receptor 40
 Protein Family    Free fatty acid receptor
 UniProt Gene Name    FFAR1 [Similar Products]
 UniProt Synonym Gene Names    GPR40 [Similar Products]
 UniProt Entry Name    FFAR1_HUMAN
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 NCBI Summary for FFAR1    This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
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 UniProt Comments for FFAR1    FFAR1: Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; lipid binding; bioactive lipid receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; insulin secretion; energy reserve metabolic process; glucose homeostasis; positive regulation of calcium ion transport; regulation of insulin secretion; positive regulation of GTPase activity
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 Research Articles on FFAR1    1. the crystal structure of hGPR40 receptor bound to TAK-875 at 2.3 A resolution
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FFAR1 antibodyPathways associated with anti-FFAR1 antibody
 Reference Product  PubMed Publications
 FFAR2 antibody  >7 publications with FFAR1 and FFAR2
 CCK antibody  >5 publications with FFAR1 and CCK
 GCG antibody  >1 publications with FFAR1 and GCG
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fatty Acids Bound To GPR40 (FFAR1) Regulate Insulin Secretion Pathway antibodies  Fatty Acids Bound To GPR40 (FFAR1) Regulate Insulin Secretion Pathway Diagram
 Free Fatty Acid Receptors Pathway antibodies  Free Fatty Acid Receptors Pathway Diagram
 Free Fatty Acids Regulate Insulin Secretion Pathway antibodies  Free Fatty Acids Regulate Insulin Secretion Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
Diseases associated with anti-FFAR1 antibodyOrgans/Tissues associated with anti-FFAR1 antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >18 publications with FFAR1 and Insulin Resistance
 Hypoglycemia Antibodies  >13 publications with FFAR1 and Hypoglycemia
 Diabetes Mellitus, Experimental Antibodies  >5 publications with FFAR1 and Diabetes Mellitus, Experimental
 Fatty Liver Antibodies  >5 publications with FFAR1 and Fatty Liver
 Breast Neoplasms Antibodies  >4 publications with FFAR1 and Breast Neoplasms
 Diabetes Complications Antibodies  >3 publications with FFAR1 and Diabetes Complications
 Melanoma Antibodies  >1 publications with FFAR1 and Melanoma
 Carcinoma Antibodies  >1 publications with FFAR1 and Carcinoma
 Lung Diseases Antibodies  >1 publications with FFAR1 and Lung Diseases
 Ischemia Antibodies  >1 publications with FFAR1 and Ischemia
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >41 publications with FFAR1 and Pancreas
 Brain Antibodies  >4 publications with FFAR1 and Brain
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