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anti-FFAR2 antibody :: Rabbit FFAR2 / GPR43 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240941
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FFAR2 / GPR43, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human FFAR2 / GPR43

 Product Synonym Names    Anti-FFAR2 / GPR43 Antibody (Extracellular Domain) IHC-plus; FFAR2; FFA2R; Free fatty acid receptor 2; G protein-coupled receptor 43; G-protein coupled receptor 43; LSSIG; GPR43; Gpcr43; Human FFAR2; GPR43
 Product Gene Name   

anti-FFAR2 antibody

[Similar Products]
 Product Synonym Gene Name    GPR43 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603823
 3D Structure    ModBase 3D Structure for O15552
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
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 Specificity    Human GPR43. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FFAR3 (47%).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 17 amino acid peptide from 2nd extracellular domain of human GPR43. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey (94%); Mouse, Rat, Dog, Panda, Rabbit, Pig (88%); Horse, Opossum (82%).
 Immunogen Type    Synthetic peptide
 Immunogen    FFAR2 / GPR43 antibody was raised against synthetic 17 amino acid peptide from 2nd extracellular domain of human GPR43. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey (94%); Mouse, Rat, Dog, Panda, Rabbit, Pig (88%); Horse, Opossum (82%).
 Antigen Modification    Extracellular Domain
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-FFAR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FFAR2 antibody

   GPR43 is classified as a Carboxylic Acid GPCR. The location of this receptor in the immune system is suggestive of potential roles in immune cell function and hematopoiesis.
 Product Categories/Family for anti-FFAR2 antibody    Family: GPCR
Subfamily: Carboxylic Acid
 Applications Tested/Suitable for anti-FFAR2 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-FFAR2 antibody    IHC-P (35 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-FFAR2 antibody    Anti-FFAR2 / GPR43 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-FFAR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FFAR2 antibody    Anti-FFAR2 / GPR43 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-FFAR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FFAR2 antibody    Anti-GPR43 antibody IHC of human lung, alveolar macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-FFAR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FFAR2 antibody    Anti-FFAR2 / GPR43 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-FFAR2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FFAR2. It may not necessarily be applicable to this product.
 NCBI GI #    4885333
 NCBI GeneID    2867
 NCBI Accession #    NP_005297.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005306.2 [Other Products]
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 UniProt Primary Accession #    O15552 [Other Products]
 UniProt Secondary Accession #    Q4VAZ3; Q4VAZ5; Q4VBL5; B0M0J9 [Other Products]
 UniProt Related Accession #    O15552 [Other Products]
 Molecular Weight    37,144 Da
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 NCBI Official Full Name    free fatty acid receptor 2
 NCBI Official Synonym Full Names    free fatty acid receptor 2
 NCBI Official Symbol    FFAR2 [Similar Products]
 NCBI Official Synonym Symbols   
FFA2R; GPR43
[Similar Products]
 NCBI Protein Information    free fatty acid receptor 2; G protein-coupled receptor 43; G-protein coupled receptor 43; free fatty acid activated receptor 2
 UniProt Protein Name    Free fatty acid receptor 2
 UniProt Synonym Protein Names   
G-protein coupled receptor 43
 Protein Family    Free fatty acid receptor
 UniProt Gene Name    FFAR2 [Similar Products]
 UniProt Synonym Gene Names    FFA2; GPCR43; GPR43 [Similar Products]
 UniProt Entry Name    FFAR2_HUMAN
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 NCBI Summary for FFAR2    This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]
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 UniProt Comments for FFAR2    FFAR2: Receptor for short chain fatty acids through a G(i)- protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cell projection; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; lipid binding

Biological Process: fat cell differentiation; G-protein coupled receptor protein signaling pathway; sequestering of lipid; mucosal immune response; regulation of acute inflammatory response; positive regulation of cytokine production during immune response; cell surface pattern recognition receptor signaling pathway; positive regulation of acute inflammatory response to non-antigenic stimulus; glucose homeostasis; leukocyte chemotaxis during inflammatory response; positive regulation of chemokine production
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 Research Articles on FFAR2    1. [review] In vivo and in vitro studies suggest that short-chain fatty acid receptors (SCFAs) stimulate gut hormone secretion; therefore, the SCFA-FFA signal is likely to be important for gut physiological functions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FFAR2 antibodyPathways associated with anti-FFAR2 antibody
 Reference Product  PubMed Publications
 FFAR1 antibody  >7 publications with FFAR2 and FFAR1
 CCK antibody  >1 publications with FFAR2 and CCK
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Free Fatty Acid Receptors Pathway antibodies  Free Fatty Acid Receptors Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Diseases associated with anti-FFAR2 antibodyOrgans/Tissues associated with anti-FFAR2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with FFAR2 and Inflammation
 Colitis Antibodies  >6 publications with FFAR2 and Colitis
 Fatty Liver Antibodies  >4 publications with FFAR2 and Fatty Liver
 Asthma Antibodies  >2 publications with FFAR2 and Asthma
 Liver Diseases Antibodies  >2 publications with FFAR2 and Liver Diseases
 Hyperglycemia Antibodies  >2 publications with FFAR2 and Hyperglycemia
 Disease Models, Animal Antibodies  >2 publications with FFAR2 and Disease Models, Animal
 Death Antibodies  >1 publications with FFAR2 and Death
 Nervous System Diseases Antibodies  >1 publications with FFAR2 and Nervous System Diseases
 Hypersensitivity Antibodies  >1 publications with FFAR2 and Hypersensitivity
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >2 publications with FFAR2 and Pancreas
 Lung Antibodies  >1 publications with FFAR2 and Lung
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