NP_003853.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,989 Da
NCBI Official Full Name
fibroblast growth factor 18
NCBI Official Synonym Full Names
fibroblast growth factor 18
NCBI Protein Information
fibroblast growth factor 18
UniProt Protein Name
Fibroblast growth factor 18
UniProt Synonym Protein Names
zFGF5
UniProt Synonym Gene Names
UniProt Entry Name
FGF18_HUMAN
NCBI Summary for FGF-18
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
UniProt Comments for FGF-18
FGF18: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. Belongs to the heparin-binding growth factors family.
Protein type: Secreted, signal peptide; Cytokine; Secreted
Chromosomal Location of Human Ortholog: 5q34
Cellular Component: extracellular space; extracellular region; nucleolus
Molecular Function: growth factor activity; type 2 fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; nervous system development; anatomical structure morphogenesis; intramembranous ossification; regulation of endothelial cell proliferation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; chondrocyte development; signal transduction; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of MAP kinase activity; positive regulation of chondrocyte differentiation; cell-cell signaling; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; angiogenesis; lung development; endochondral ossification
Research Articles on FGF-18
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Products associated with anti-FGF-18 antibody
Pathways associated with anti-FGF-18 antibody
Diseases associated with anti-FGF-18 antibody
Organs/Tissues associated with anti-FGF-18 antibody
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