NP_004104.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,424 Da
NCBI Official Full Name
fibroblast growth factor 12 isoform 2
NCBI Official Synonym Full Names
fibroblast growth factor 12
NCBI Official Synonym Symbols
NCBI Protein Information
fibroblast growth factor 12; FGF-12; FHF-1; fibroblast growth factor 12B; fibroblast growth factor FGF-12b; fibroblast growth factor homologous factor 1; myocyte-activating factor
UniProt Protein Name
Fibroblast growth factor 12
UniProt Synonym Protein Names
Fibroblast growth factor homologous factor 1; FHF-1; Myocyte-activating factor
UniProt Synonym Gene Names
UniProt Entry Name
FGF12_HUMAN
NCBI Summary for FGF12
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for FGF12
FGF12: Probably involved in nervous system development and function. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Cytokine
Chromosomal Location of Human Ortholog: 3q28
Cellular Component: extracellular space; nucleus
Molecular Function: heparin binding; sodium channel regulator activity; growth factor activity; fibroblast growth factor receptor binding
Biological Process: nervous system development; synaptic transmission; fibroblast growth factor receptor signaling pathway; cell-cell signaling; adult locomotory behavior; neuromuscular process; heart development; JNK cascade; signal transduction
Research Articles on FGF12
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Products associated with anti-FGF12 antibody
Pathways associated with anti-FGF12 antibody
Diseases associated with anti-FGF12 antibody
Organs/Tissues associated with anti-FGF12 antibody
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