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anti-FGFR1 antibody :: Rabbit FGFR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9204812
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FGFR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

FGFR1 Antibody (Center)

 Product Synonym Names    Fibroblast growth factor receptor 1; FGFR-1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD331; FGFR1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR
 Product Gene Name   

anti-FGFR1 antibody

[Similar Products]
 Antibody/Peptide Pairs    FGFR1 peptide (MBS9229565) is used for blocking the activity of FGFR1 antibody (MBS9204812)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    101600
 3D Structure    ModBase 3D Structure for P11362
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse (Predicted Reactivity: Chicken, Rat)
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 Specificity    This FGFR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 291-324 amino acids from the Central region of human FGFR1.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 mg/ml (lot specific)
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 Crown Antibody    Yes
 Antigen Source    HUMAN
 Cellular Location    Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus
 Tissue Location    Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-FGFR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FGFR1 antibody

   Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
 Product Categories/Family for anti-FGFR1 antibody    Crown Antibodies; Cancer; Cell Biology
 Applications Tested/Suitable for anti-FGFR1 antibody   

Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB)

 Application Notes for anti-FGFR1 antibody    FC~~1:25
WB~~1:1000
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 Flow Cytometry (FC/FACS) of anti-FGFR1 antibody    Flow cytometric analysis of SH-SY5Y cells using FGFR1 Antibody (Center)(green) compared to an isotype control of rabbit IgG(blue). MBS9204812 was diluted at 1:25 dilution. An Alexa Fluor 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.
anti-FGFR1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Western Blot (WB) of anti-FGFR1 antibody    Western blot analysis of lysates from Hela, HepG2, MCF-7, SH-SY5Y, mouse NIH/3T3 cell line (from left to right), using FGFR1 Antibody (Center). MBS9204812 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
anti-FGFR1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FGFR1. It may not necessarily be applicable to this product.
 NCBI GI #    291327489
 NCBI GeneID    2260
 NCBI Accession #    NP_001167534.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001174063.1 [Other Products]
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 UniProt Primary Accession #    P11362 [Other Products]
 UniProt Secondary Accession #    P17049; Q02063; Q02065; Q14306; Q14307; Q53H63; Q59H40; Q5BJG2; A8K6T9; A8K8V5; C1KBH8 [Other Products]
 UniProt Related Accession #    P11362 [Other Products]
 Molecular Weight    91868
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 NCBI Official Full Name    fibroblast growth factor receptor 1 isoform 10
 NCBI Official Synonym Full Names    fibroblast growth factor receptor 1
 NCBI Official Symbol    FGFR1 [Similar Products]
 NCBI Official Synonym Symbols   
CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1
[Similar Products]
 NCBI Protein Information    fibroblast growth factor receptor 1
 UniProt Protein Name    Fibroblast growth factor receptor 1
 UniProt Synonym Protein Names   
Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD_antigen: CD331
 Protein Family    FGFR1 oncogene partner
 UniProt Gene Name    FGFR1 [Similar Products]
 UniProt Synonym Gene Names    BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; FGFR-1; BFGFR; bFGF-R-1; FLT-2 [Similar Products]
 UniProt Entry Name    FGFR1_HUMAN
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 NCBI Summary for FGFR1    The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGFR1    FGFR1: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described.

Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; Oncoprotein; EC 2.7.10.1; TK group; FGFR family

Chromosomal Location of Human Ortholog: 8p11.23-p11.22

Cellular Component: integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane; integral to membrane; extracellular region; cytosol; nucleus; receptor complex

Molecular Function: heparin binding; identical protein binding; protein binding; protein homodimerization activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding

Biological Process: paraxial mesoderm development; axon guidance; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; cell maturation; neuron migration; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; protein amino acid phosphorylation; positive regulation of MAP kinase activity; sensory perception of sound; positive regulation of MAPKKK cascade; ureteric bud development; induction of an organ; regulation of cell differentiation; midbrain development; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; chondrocyte differentiation; angiogenesis; skeletal development; embryonic limb morphogenesis; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; inner ear morphogenesis; cell migration; chordate embryonic development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; transcription, DNA-dependent; in utero embryonic development; outer ear morphogenesis; MAPKKK cascade; positive regulation of cell cycle; positive regulation of phosphoinositide 3-kinase cascade; neuroblast division in the ventricular zone; mesenchymal cell differentiation; skeletal morphogenesis; insulin receptor signaling pathway; innate immune response; auditory receptor cell development; positive regulation of neuron differentiation; regulation of lateral mesodermal cell fate specification

Disease: Pfeiffer Syndrome; Hypogonadotropic Hypogonadism 2 With Or Without Anosmia; Jackson-weiss Syndrome; Trigonocephaly 1; Osteoglophonic Dysplasia
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Product References and Citations for anti-FGFR1 antibody

   Itoh N.,et al.Biochem. Biophys. Res. Commun. 169:680-685(1990).
Dionne C.A.,et al.EMBO J. 9:2685-2692(1990).
Johnson D.E.,et al.Mol. Cell. Biol. 10:4728-4736(1990).
Isacchi A.,et al.Nucleic Acids Res. 18:1906-1906(1990).
Wennstroem S.,et al.Growth Factors 4:197-208(1991).
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 Research Articles on FGFR1    1. Studies indicate that the overall survival was significantly worse among patients with fibroblast growth factor receptor FGFR1 and FGFR2 gene amplification: FGFR1 (hazard risk 1.57) and FGFR2 (hazard risk 2.27).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-FGFR1 antibodyDiseases associated with anti-FGFR1 antibody
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 D-Glutamine And D-glutamate Metabolism Pathway antibodies  D-Glutamine And D-glutamate Metabolism Pathway Diagram
 D-Glutamine And D-glutamate Metabolism Pathway antibodies  D-Glutamine And D-glutamate Metabolism Pathway Diagram
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 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >143 publications with FGFR1 and Nervous System Diseases
 Myeloproliferative Disorders Antibodies  >139 publications with FGFR1 and Myeloproliferative Disorders
 Disease Models, Animal Antibodies  >136 publications with FGFR1 and Disease Models, Animal
 Craniofacial Abnormalities Antibodies  >132 publications with FGFR1 and Craniofacial Abnormalities
 Kallmann Syndrome Antibodies  >129 publications with FGFR1 and Kallmann Syndrome
 Breast Neoplasms Antibodies  >113 publications with FGFR1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >96 publications with FGFR1 and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >77 publications with FGFR1 and Carcinoma, Squamous Cell
 TRIGONOCEPHALY 1 Antibodies  >69 publications with FGFR1 and TRIGONOCEPHALY 1
 Small Cell Lung Carcinoma Antibodies  >63 publications with FGFR1 and Small Cell Lung Carcinoma
Organs/Tissues associated with anti-FGFR1 antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >346 publications with FGFR1 and Vascular
 Blood Antibodies  >342 publications with FGFR1 and Blood
 Brain Antibodies  >340 publications with FGFR1 and Brain
 Bone Antibodies  >326 publications with FGFR1 and Bone
 Embryonic Tissue Antibodies  >226 publications with FGFR1 and Embryonic Tissue
 Nerve Antibodies  >218 publications with FGFR1 and Nerve
 Muscle Antibodies  >214 publications with FGFR1 and Muscle
 Lung Antibodies  >186 publications with FGFR1 and Lung
 Kidney Antibodies  >104 publications with FGFR1 and Kidney
 Bone Marrow Antibodies  >102 publications with FGFR1 and Bone Marrow
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