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anti-FHL2 antibody :: Goat FHL2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420475
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FHL2, Polyclonal Antibody

 Also Known As   

Goat anti-FHL2 Antibody

 Product Synonym Names    FHL2; DRAL; AAG11; SLIM3; four and a half LIM domains 2; down-regulated in rhabdomyosarcoma LIM protein; aging-associated gene 11; four and a half LIM-domain protein 2; OTTHUMP00000203164; OTTHUMP00000203168; OTTHUMP00000203169; FHL2 antibody; DRAL antibody; AAG11 antibody; SLIM3 antibody; four and a half LIM domains 2 antibody; down-regulated in rhabdomyosarcoma LIM protein antibody; aging-associated gene 11 antibody; four and a half LIM-domain protein 2 antibody; OTTHUMP00000203164 antibody; OTTHUMP00000203168 antibody; OTTHUMP00000203169 antibody
 Product Gene Name   

anti-FHL2 antibody

[Similar Products]
 Antibody/Peptide Pairs    FHL2 peptide (MBS425449) is used for blocking the activity of FHL2 antibody (MBS420475)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    RDDILCPDCG KDI
 OMIM    602633
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence RDDILCPDCGKDI, from the C Terminus of the protein sequence according to NP_001441.4.
 Epitope    C Terminus
 Note    Reported variants represent identical protein (NP_001441.4; NP_963849.1; NP_963851.2; NP_001034581.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-FHL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FHL2 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-FHL2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 30kDa band observed in Human and Mouse Heart lysates (calculated MW of 32.2kDa according to NP_001441.4). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-FHL2 antibody    (1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-FHL2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FHL2. It may not necessarily be applicable to this product.
 NCBI GI #    87159832
 NCBI GeneID    2274
 NCBI Accession #    NP_001441.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_001450.3 [Other Products]
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 UniProt Secondary Accession #    Q13229; Q13644; Q2I5I4; Q5TM15; Q9P294 [Other Products]
 UniProt Related Accession #    Q14192 [Other Products]
 Molecular Weight    15,890 Da
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 NCBI Official Full Name    four and a half LIM domains protein 2 isoform a
 NCBI Official Synonym Full Names    four and a half LIM domains 2
 NCBI Official Symbol    FHL2 [Similar Products]
 NCBI Official Synonym Symbols   
DRAL; AAG11; FHL-2; SLIM3; SLIM-3
[Similar Products]
 NCBI Protein Information    four and a half LIM domains protein 2
 UniProt Protein Name    Four and a half LIM domains protein 2
 UniProt Synonym Protein Names   
LIM domain protein DRAL; Skeletal muscle LIM-protein 3; SLIM-3
 Protein Family    Four and a half LIM domains protein
 UniProt Gene Name    FHL2 [Similar Products]
 UniProt Synonym Gene Names    DRAL; SLIM3; FHL-2; SLIM-3 [Similar Products]
 UniProt Entry Name    FHL2_HUMAN
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 NCBI Summary for FHL2    This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
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 UniProt Comments for FHL2    FHL2: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q12.2

Cellular Component: actin cytoskeleton; focal adhesion; M band; nucleoplasm; nucleus; Z disc

Molecular Function: androgen receptor binding; identical protein binding; protein binding; transcription coactivator activity; transcription factor binding; zinc ion binding

Biological Process: androgen receptor signaling pathway; atrial cardiac muscle cell development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; positive regulation of transcription, DNA-dependent; response to hormone stimulus; transcription, DNA-dependent; ventricular cardiac muscle cell development
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 Research Articles on FHL2    1. we conclude that FHL2 has both structural and functional protein-protein interactions with b-catenin in the podocyte nucleus and that FHL2 protein inhibition can mitigate Wnt/b-catenin-induced podocytopathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FHL2 antibodyPathways associated with anti-FHL2 antibody
 Reference Product  PubMed Publications
 SRF antibody  >7 publications with FHL2 and SRF
 TRAF6 antibody  >4 publications with FHL2 and TRAF6
 TP53 antibody  >3 publications with FHL2 and TP53
 FOXO1 antibody  >2 publications with FHL2 and FOXO1
 TTN antibody  >1 publications with FHL2 and TTN
 IGFBP5 antibody  >1 publications with FHL2 and IGFBP5
 EP300 antibody  >1 publications with FHL2 and EP300
 SIRT1 antibody  >1 publications with FHL2 and SIRT1
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 RANKL/RANK Signaling Pathway antibodies  RANKL/RANK Signaling Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
Diseases associated with anti-FHL2 antibodyOrgans/Tissues associated with anti-FHL2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >24 publications with FHL2 and Cardiovascular Diseases
 Carcinoma Antibodies  >22 publications with FHL2 and Carcinoma
 Heart Diseases Antibodies  >20 publications with FHL2 and Heart Diseases
 Disease Models, Animal Antibodies  >15 publications with FHL2 and Disease Models, Animal
 Hypertrophy Antibodies  >13 publications with FHL2 and Hypertrophy
 Prostatic Neoplasms Antibodies  >11 publications with FHL2 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >11 publications with FHL2 and Breast Neoplasms
 Inflammation Antibodies  >10 publications with FHL2 and Inflammation
 Necrosis Antibodies  >9 publications with FHL2 and Necrosis
 Liver Diseases Antibodies  >9 publications with FHL2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >183 publications with FHL2 and Muscle
 Heart Antibodies  >49 publications with FHL2 and Heart
 Blood Antibodies  >46 publications with FHL2 and Blood
 Bone Antibodies  >29 publications with FHL2 and Bone
 Bone Marrow Antibodies  >20 publications with FHL2 and Bone Marrow
 Prostate Antibodies  >18 publications with FHL2 and Prostate
 Liver Antibodies  >17 publications with FHL2 and Liver
 Lung Antibodies  >12 publications with FHL2 and Lung
 Embryonic Tissue Antibodies  >10 publications with FHL2 and Embryonic Tissue
 Kidney Antibodies  >10 publications with FHL2 and Kidney
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