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anti-Angptl4 antibody :: Rabbit anti-Rat FIAF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS618422 anti-Angptl4 antibody
Unit / Price
0.1 mg  /  $665 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FIAF (Angptl4), Polyclonal Antibody

 Also Known As   

FIAF (Fasting-induced Adipose Factor, Angiopoietin-like Protein 4, ANGPTL 4, PPAR gamma Angiopoitein-related Protein, PGAR, Hepatic Fibrinogen Angiopoietin-related Protein, HFARP)

 Product Synonym Names    Anti -FIAF (Fasting-induced Adipose Factor, Angiopoietin-like Protein 4, ANGPTL 4, PPAR gamma Angiopoitein-related Protein, PGAR, Hepatic Fibrinogen Angiopoietin-related Protein, HFARP)
 Product Gene Name   

anti-Angptl4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000083.5 (33911845..33918520, complement). Location: 17 B1; 17
 3D Structure    ModBase 3D Structure for Q9Z1P8
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    Recognizes rat ANGPTL4.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS containing 1mg/ml BSA and 0.05% sodium azide.
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 Immunogen    Synthetic peptide corresponding to aa 80-94 (CQGPKGKDAPFKDSE) of mouse ANGPTL4 (angiopoietin-like protein 4)
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Angptl4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Angptl4 antibody

   Adipose tissue is an energy reserve in animals and, in nondomestic species, is strictly regulated. Adipose cells produce and secrete numerous physiologically important proteins that help regulate whole body metabolism, such as leptin and adiponectin. Fasting causes significant changes in nutrient metabolism and many of these changes are controlled by transcription factors that regulate rate-limiting enzymes. An important transcription factor that mediates metabolic processes induced by fasting is peroxisome proliferator-activated receptor (PPAR). PPAR has been reported to target a gene encoding the secreted protein ANGPTL4 (angiopoietin-like protein 4; FIAF; fasting-induced adipose factor). ANGPTL4 is expressed predominantly in adipose tissue and is strongly upregulated in white adipose tissue and the liver under fasting conditions. Initial studies suggest that ANGPTL4 represents an endocrine signal helping to regulate metabolism, especially under fasting conditions.
 Product Categories/Family for anti-Angptl4 antibody    Antibodies; Abs to Hormones, Steroids
 Applications Tested/Suitable for anti-Angptl4 antibody   

Western Blot (WB)

 Application Notes for anti-Angptl4 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 2ug/ml. Detects a band of ~50kD.
Optimal dilution determined by the researcher.
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NCBI/Uniprot data below describe general gene information for Angptl4. It may not necessarily be applicable to this product.
 NCBI GI #    9255877
 NCBI GeneID    57875
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 UniProt Primary Accession #    Q9Z1P8 [Other Products]
 UniProt Secondary Accession #    Q78ZJ9; Q9JHX7; Q9JLX7 [Other Products]
 UniProt Related Accession #    Q3UYS5; Q8CEZ7; Q9Z1P8 [Other Products]
 Molecular Weight    45,538 Da [Similar Products]
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 NCBI Official Full Name    fasting-induced adipose factor
 NCBI Official Synonym Full Names    angiopoietin-like 4
 NCBI Official Symbol    Angptl4 [Similar Products]
 NCBI Official Synonym Symbols   
Arp4; Bk89; Fiaf; Ng27; Pgar; Hfarp; Pgarg; Pp1158
[Similar Products]
 NCBI Protein Information    angiopoietin-related protein 4; 425O18-1; secreted protein Bk89; angiopoietin-like protein 4; fasting-induced adipose factor; fibrinogen/angiopoietin-related protein; major histocompatibility complex region NG27; hepatic fibrinogen/angiopoietin-related protein
 UniProt Protein Name    Angiopoietin-related protein 4
 UniProt Synonym Protein Names   
425O18-1; Angiopoietin-like protein 4; Fasting-induced adipose factor; Hepatic fibrinogen/angiopoietin-related protein; HFARP; Secreted protein Bk89
 Protein Family    Angiopoietin-related protein
 UniProt Gene Name    Angptl4 [Similar Products]
 UniProt Synonym Gene Names    Farp; Fiaf; Ng27 [Similar Products]
 UniProt Entry Name    ANGL4_MOUSE
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 UniProt Comments for Angptl4    ANGPTL4: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Protein type: Apoptosis; Extracellular matrix; Secreted, signal peptide; Inhibitor; Secreted

Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: enzyme inhibitor activity

Biological Process: positive regulation of lipid metabolic process; negative regulation of lipoprotein lipase activity; angiogenesis; cellular response to starvation; protein homooligomerization; negative regulation of apoptosis
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 Research Articles on Angptl4    1. the cleavage of ANGPTL4 by these PCs modulates its inhibitory effect on LPL activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Angptl4 antibodyDiseases associated with anti-Angptl4 antibody
 Products by Pathway  Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
 Disease Name  Pubmed Publications
 Obesity Antibodies  >31 publications with Angptl4 and Obesity
 Neoplasms Antibodies  >30 publications with Angptl4 and Neoplasms
 Carcinoma Antibodies  >21 publications with Angptl4 and Carcinoma
 Inflammation Antibodies  >14 publications with Angptl4 and Inflammation
 Fatty Liver Antibodies  >12 publications with Angptl4 and Fatty Liver
 Vascular Diseases Antibodies  >12 publications with Angptl4 and Vascular Diseases
 Neoplasm Metastasis Antibodies  >12 publications with Angptl4 and Neoplasm Metastasis
 Metaplasia Antibodies  >11 publications with Angptl4 and Metaplasia
 Diabetes Mellitus Antibodies  >10 publications with Angptl4 and Diabetes Mellitus
 Atherosclerosis Antibodies  >10 publications with Angptl4 and Atherosclerosis
Organs/Tissues associated with anti-Angptl4 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >73 publications with Angptl4 and Blood
 Liver Antibodies  >35 publications with Angptl4 and Liver
 Connective Tissue Antibodies  >25 publications with Angptl4 and Connective Tissue
 Muscle Antibodies  >22 publications with Angptl4 and Muscle
 Brain Antibodies  >15 publications with Angptl4 and Brain
 Intestine Antibodies  >13 publications with Angptl4 and Intestine
 Lung Antibodies  >10 publications with Angptl4 and Lung
 Kidney Antibodies  >9 publications with Angptl4 and Kidney
 Lymph Node Antibodies  >8 publications with Angptl4 and Lymph Node
 Prostate Antibodies  >5 publications with Angptl4 and Prostate
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