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anti-FGA antibody :: Sheep FIBRINOGEN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS222660 anti-FGA antibody
Unit / Price
1 mL  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FIBRINOGEN (FGA), Polyclonal Antibody

 Also Known As   

SHEEP ANTI HUMAN FIBRINOGEN:FITC

 Product Gene Name   

anti-FGA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    105200
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Sheep
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
 Buffer Solution    Phosphate buffered saline
 Antiserum Preparation    Antisera to human fibrinogen were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-FGA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FGA antibody

   Sheep anti Human fibrinogen antibody recognizes human fibrinogen, a complex ~340kDa hetero-hexameric (di-trimeric) glycoprotein consisting of 3 pairs of alpha, beta and gamma chains linked by a series of 29 disulphide bonds (Henschen et al. 1983). The six chains are arranged in such a way that all the N-Terminal ends adjoin to form a central E domain with two trimeric coiled coil structures connecting to outer D domains. Fibrinogen plays an important role in the coagulation process with the D and E domains interacting via the C-Terminal ends of the alpha chains during fibrin clot cross-linking. Sheep anti human fibrinogen antibody shows minimal cross-reactivity with related serum proteins. Fibrinogen has been identified as a ferritin binding protein in the horse (Orino et al. 1993). Sheep anti human fibrinogen antibody has been successfully as a capture reagent for ferritin - anti ferritin IgG complexes in horse plasma to evaluate the antibody response to ferritin by ELISA (Takahashi et al. 2013).
 Applications Tested/Suitable for anti-FGA antibody   

Immunofluorescence (IF)

 Application Notes for anti-FGA antibody    Immunofluorescence: Minimum Dilution: 1/10; Maximum Dilution: 1/100
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NCBI/Uniprot data below describe general gene information for FGA. It may not necessarily be applicable to this product.
 NCBI GI #    4503689
 NCBI GeneID    2243
 NCBI Accession #    NP_000499.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000508.3 [Other Products]
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 UniProt Secondary Accession #    Q4QQH7; Q9BX62; Q9UCH2; A8K3E4; D3DP14; D3DP15 [Other Products]
 UniProt Related Accession #    P02671 [Other Products]
 Molecular Weight    69,757 Da [Similar Products]
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 NCBI Official Full Name    fibrinogen alpha chain isoform alpha-E preproprotein
 NCBI Official Synonym Full Names    fibrinogen alpha chain
 NCBI Official Symbol    FGA [Similar Products]
 NCBI Official Synonym Symbols   
Fib2
[Similar Products]
 NCBI Protein Information    fibrinogen alpha chain; fibrinogen, A alpha polypeptide
 UniProt Protein Name    Fibrinogen alpha chain
 Protein Family    Fibrinogen
 UniProt Gene Name    FGA [Similar Products]
 UniProt Entry Name    FIBA_HUMAN
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 NCBI Summary for FGA    The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGA    FGA: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGA are a cause of congenital afibrinogenemia (CAFBN). This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha- dysfibrinogenemias. Defects in FGA are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q28

Cellular Component: extracellular space; cell surface; fibrinogen complex; plasma membrane; extracellular region; cell cortex; vesicle; external side of plasma membrane

Molecular Function: protein binding, bridging; protein binding; cell adhesion molecule binding; structural molecule activity; receptor binding

Biological Process: protein polymerization; platelet activation; extracellular matrix organization and biogenesis; cellular protein complex assembly; positive regulation of heterotypic cell-cell adhesion; platelet degranulation; positive regulation of protein secretion; cell-matrix adhesion; positive regulation of vasoconstriction; innate immune response; blood coagulation; response to calcium ion; signal transduction; positive regulation of exocytosis

Disease: Amyloidosis, Familial Visceral; Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital
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 Research Articles on FGA    1. Results show that oxidized fibrinogen, instead of serum albumin (HSA), is the key protein for intermolecular dityrosine formation in plasma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FGA antibodyPathways associated with anti-FGA antibody
 Reference Product  PubMed Publications
 FGB antibody  >88 publications with FGA and FGB
 FGG antibody  >80 publications with FGA and FGG
 F13A1 antibody  >10 publications with FGA and F13A1
 F13B antibody  >8 publications with FGA and F13B
 APOA1 antibody  >3 publications with FGA and APOA1
 ITGA2B antibody  >2 publications with FGA and ITGA2B
 ITGB3 antibody  >2 publications with FGA and ITGB3
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 GRB2:SOS Provides Linkage To MAPK Signaling For Integrins Pathway antibodies  GRB2:SOS Provides Linkage To MAPK Signaling For Integrins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-FGA antibodyOrgans/Tissues associated with anti-FGA antibody
 Disease Name  Pubmed Publications
 Afibrinogenemia Antibodies  >57 publications with FGA and Afibrinogenemia
 Afibrinogenemia congenital Antibodies  >55 publications with FGA and Afibrinogenemia congenital
 Cardiovascular Diseases Antibodies  >53 publications with FGA and Cardiovascular Diseases
 Brain Diseases Antibodies  >37 publications with FGA and Brain Diseases
 Thrombosis Antibodies  >20 publications with FGA and Thrombosis
 Death Antibodies  >18 publications with FGA and Death
 Weight Gain Antibodies  >16 publications with FGA and Weight Gain
 Hemorrhage Antibodies  >13 publications with FGA and Hemorrhage
 Inflammation Antibodies  >13 publications with FGA and Inflammation
 Hypertension Antibodies  >10 publications with FGA and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >194 publications with FGA and Blood
 Brain Antibodies  >28 publications with FGA and Brain
 Liver Antibodies  >21 publications with FGA and Liver
 Lung Antibodies  >17 publications with FGA and Lung
 Heart Antibodies  >17 publications with FGA and Heart
 Kidney Antibodies  >9 publications with FGA and Kidney
 Muscle Antibodies  >8 publications with FGA and Muscle
 Uterus Antibodies  >5 publications with FGA and Uterus
 Embryonic Tissue Antibodies  >5 publications with FGA and Embryonic Tissue
 Spleen Antibodies  >3 publications with FGA and Spleen
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