NP_002007.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
filaggrin
NCBI Official Synonym Full Names
filaggrin
NCBI Official Synonym Symbols
NCBI Protein Information
filaggrin
UniProt Protein Name
Filaggrin
NCBI Summary for FILA
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
UniProt Comments for FILA
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Research Articles on FILA
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Products associated with anti-FILA antibody
Pathways associated with anti-FILA antibody
Diseases associated with anti-FILA antibody
Disease Name |
Pubmed Publications |
Dermatitis, Atopic Antibodies |
>145 publications with FILA and Dermatitis, Atopic |
Dermatitis, Atopic, 1 Antibodies |
>79 publications with FILA and Dermatitis, Atopic, 1 |
Dermatitis, Atopic, 2 Antibodies |
>69 publications with FILA and Dermatitis, Atopic, 2 |
Eczema Antibodies |
>62 publications with FILA and Eczema |
Ichthyosis Antibodies |
>60 publications with FILA and Ichthyosis |
Neoplasms Antibodies |
>58 publications with FILA and Neoplasms |
Ichthyosis Vulgaris Antibodies |
>56 publications with FILA and Ichthyosis Vulgaris |
Lung Diseases Antibodies |
>28 publications with FILA and Lung Diseases |
Inflammation Antibodies |
>23 publications with FILA and Inflammation |
Necrosis Antibodies |
>12 publications with FILA and Necrosis |
Organs/Tissues associated with anti-FILA antibody
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