NP_001269912.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,263 Da
NCBI Official Full Name
FERM, RhoGEF and pleckstrin domain-containing protein 2 isoform b
NCBI Official Synonym Full Names
FERM, RhoGEF and pleckstrin domain protein 2
NCBI Protein Information
FERM, RhoGEF and pleckstrin domain-containing protein 2
UniProt Protein Name
FERM, RhoGEF and pleckstrin domain-containing protein 2
UniProt Synonym Protein Names
FERM domain including RhoGEF; FIR; Pleckstrin homology domain-containing family C member 3; PH domain-containing family C member 3
UniProt Synonym Gene Names
KIAA0793; PLEKHC3; FIR; PH domain-containing family C member 3 [Similar Products]
UniProt Entry Name
FARP2_HUMAN
UniProt Comments for FIR
FARP2: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; Motility/polarity/chemotaxis; Cell development/differentiation; GEFs, Rac/Rho
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cytoskeleton; extrinsic to membrane; cytoplasm; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; cytoskeletal protein binding
Biological Process: axon guidance; regulation of integrin activation; actin cytoskeleton reorganization; Rac protein signal transduction; osteoclast differentiation; cell adhesion; neuron remodeling
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Products associated with anti-FIR antibody
Pathways associated with anti-FIR antibody
Diseases associated with anti-FIR antibody
Organs/Tissues associated with anti-FIR antibody
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