NP_001269912.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform b
NCBI Official Synonym Full Names
FERM, ARH/RhoGEF and pleckstrin domain protein 2
NCBI Protein Information
FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2
UniProt Protein Name
FERM, ARHGEF and pleckstrin domain-containing protein 2
UniProt Synonym Protein Names
FERM domain-including RhoGEF; FIR; FERM, RhoGEF and pleckstrin domain-containing protein 2; Pleckstrin homology domain-containing family C member 3; PH domain-containing family C member 3
UniProt Synonym Gene Names
KIAA0793; PLEKHC3; FIR; PH domain-containing family C member 3 [Similar Products]
UniProt Comments for FIR
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion ().
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Products associated with anti-FIR antibody
Pathways associated with anti-FIR antibody
Diseases associated with anti-FIR antibody
Organs/Tissues associated with anti-FIR antibody
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