BC001670
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Friend leukemia integration 1 transcription factor isoform 4
NCBI Official Synonym Full Names
Fli-1 proto-oncogene, ETS transcription factor
NCBI Official Synonym Symbols
NCBI Protein Information
Friend leukemia integration 1 transcription factor; Ewing sarcoma breakpoint region 2; Friend leukemia virus integration 1; transcription factor ERGB
UniProt Protein Name
Friend leukemia integration 1 transcription factor
UniProt Synonym Protein Names
Proto-oncogene Fli-1; Transcription factor ERGB
UniProt Entry Name
FLI1_HUMAN
NCBI Summary for FLI1
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Comments for FLI1
FLI1: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. Defects in FLI1 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 11q24.1-q24.3
Cellular Component: nucleus
Molecular Function: DNA binding; chromatin binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; blood circulation; hemostasis; positive regulation of transcription from RNA polymerase II promoter; cell differentiation
Research Articles on FLI1
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Products associated with anti-FLI1 antibody
Pathways associated with anti-FLI1 antibody
Diseases associated with anti-FLI1 antibody
Organs/Tissues associated with anti-FLI1 antibody
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