NP_001157789.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
filamin-B isoform 1
NCBI Official Synonym Full Names
filamin B, beta
NCBI Official Synonym Symbols
AOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280 [Similar Products]
NCBI Protein Information
filamin-B
UniProt Protein Name
Filamin-B
UniProt Synonym Protein Names
ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP
UniProt Synonym Gene Names
UniProt Entry Name
FLNB_HUMAN
NCBI Summary for FLNB
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for FLNB
FLNB: a ubiquitous cytoskeletal protein that links actin filaments to membrane glycoproteins. Six alternatively spliced isoforms have been described. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoforms 1 and 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells, retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord and platelets. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer's disease. Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.
Protein type: Motility/polarity/chemotaxis; Actin-binding
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: focal adhesion; cytoplasm; plasma membrane; stress fiber; integral to membrane; cell cortex; cytosol; Z disc; brush border; actin cytoskeleton
Molecular Function: identical protein binding; protein binding; actin binding
Biological Process: skeletal muscle development; cytoskeletal anchoring; cytokine and chemokine mediated signaling pathway; signal transduction; actin cytoskeleton organization and biogenesis
Disease: Larsen Syndrome; Boomerang Dysplasia; Atelosteogenesis, Type I; Spondylocarpotarsal Synostosis Syndrome; Atelosteogenesis, Type Iii
Product References and Citations for anti-FLNB antibody
Takafuta T.,et al.J. Biol. Chem. 273:17531-17538(1998).
Xu W.-F.,et al.Blood 92:1268-1276(1998).
van Der Flier A.,et al.J. Cell Biol. 156:361-376(2002).
Chakarova C.,et al.Hum. Genet. 107:597-611(2000).
Oshikawa M.,et al.DNA Res. 15:123-136(2008).
Research Articles on FLNB
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Pathways associated with anti-FLNB antibody
Diseases associated with anti-FLNB antibody
Organs/Tissues associated with anti-FLNB antibody
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