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anti-FLT1 antibody :: Rabbit FLT1 / VEGFR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240184
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FLT1 / VEGFR1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human FLT1 / VEGFR1

 Product Synonym Names    Anti-FLT1 / VEGFR1 Antibody (C-Terminus) IHC-plus; FLT1; FLT; FLT-1; Fms-related tyrosine kinase 1; SFlt1; VEGF-r1; VEG-R1; Tyrosine-protein kinase FRT; VEGFR-1; Fms-like tyrosine kinase 1; FRT; VEGF receptor 1; VEGFf-rI; VEGFR1; Human FLT1; VEGFR1
 Product Gene Name   

anti-FLT1 antibody

[Similar Products]
 Product Synonym Gene Name    VEGFR1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    165070
 3D Structure    ModBase 3D Structure for P17948
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gorilla, Human
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 Specificity    Human VEGFR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 17 amino acid peptide from C-terminus of human VEGFR1. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey (88%); Gibbon (82%).
 Immunogen Type    Synthetic peptide
 Immunogen    FLT1 / VEGFR1 antibody was raised against synthetic 17 amino acid peptide from C-terminus of human VEGFR1. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey (88%); Gibbon (82%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-FLT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-FLT1 antibody

   FLT1 (fms-like tyrosine kinase/vascular endothelial growth factor receptor 1) is a receptor for VEGR, VEGFB, and PGF. This receptor has a large extracellular domain similar to other members of the fms family and has tyrosine kinase activity. The VEGF kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.
 Product Categories/Family for anti-FLT1 antibody    Family: Protein Kinase
Subfamily: VEGF Receptor
 Applications Tested/Suitable for anti-FLT1 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-FLT1 antibody    IHC-P (5 - 10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-FLT1 antibody    Anti-VEGFR1 antibody IHC of human placenta, fetal capillary endothelial cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-FLT1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FLT1. It may not necessarily be applicable to this product.
 NCBI GI #    156104876
 NCBI GeneID    2321
 NCBI Accession #    NP_002010.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002019.4 [Other Products]
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 UniProt Primary Accession #    P17948 [Other Products]
 UniProt Secondary Accession #    O60722; A3E342; A3E344; A8KA71; B0LPF1; B2BF46; B2BF47; B2BF48; B3FR89; B5A923; F5H5L6 [Other Products]
 UniProt Related Accession #    P17948 [Other Products]
 Molecular Weight    41,175 Da
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 NCBI Official Full Name    vascular endothelial growth factor receptor 1 isoform 1
 NCBI Official Synonym Full Names    fms-related tyrosine kinase 1
 NCBI Official Symbol    FLT1 [Similar Products]
 NCBI Official Synonym Symbols   
FLT; FLT-1; VEGFR1; VEGFR-1
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor receptor 1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
 UniProt Protein Name    Vascular endothelial growth factor receptor 1
 UniProt Synonym Protein Names   
Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptor
 Protein Family    Vascular endothelial growth factor receptor
 UniProt Gene Name    FLT1 [Similar Products]
 UniProt Synonym Gene Names    FLT; FRT; VEGFR1; VEGFR-1; FLT-1; FLT [Similar Products]
 UniProt Entry Name    VGFR1_HUMAN
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 NCBI Summary for FLT1    This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
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 UniProt Comments for FLT1    VEGFR1: a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Protein type: Protein kinase, TK; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; VEGFR family

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: extracellular space; focal adhesion; integral to plasma membrane; plasma membrane; receptor complex; endosome

Molecular Function: identical protein binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; patterning of blood vessels; positive regulation of phosphoinositide 3-kinase cascade; monocyte chemotaxis; positive regulation of MAP kinase activity; positive regulation of angiogenesis; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; blood vessel morphogenesis; embryonic morphogenesis; sprouting angiogenesis; cell differentiation; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
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 Research Articles on FLT1    1. Data indicate that FLT1 receptor tyrosine kinase was overexpressed in primary colorectal carcinoma (CRC) and their nodal metastases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FLT1 antibodyPathways associated with anti-FLT1 antibody
 Reference Product  PubMed Publications
 VEGFA antibody  >167 publications with FLT1 and VEGFA
 HIF1A antibody  >38 publications with FLT1 and HIF1A
 PGF antibody  >19 publications with FLT1 and PGF
 VEGFC antibody  >15 publications with FLT1 and VEGFC
 VEGFB antibody  >10 publications with FLT1 and VEGFB
 NRP1 antibody  >8 publications with FLT1 and NRP1
 EPAS1 antibody  >5 publications with FLT1 and EPAS1
 FIGF antibody  >4 publications with FLT1 and FIGF
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
Diseases associated with anti-FLT1 antibodyOrgans/Tissues associated with anti-FLT1 antibody
 Disease Name  Pubmed Publications
 Pre-Eclampsia Antibodies  >309 publications with FLT1 and Pre-Eclampsia
 Hypertension Antibodies  >129 publications with FLT1 and Hypertension
 Disease Models, Animal Antibodies  >120 publications with FLT1 and Disease Models, Animal
 Proteinuria Antibodies  >69 publications with FLT1 and Proteinuria
 Inflammation Antibodies  >53 publications with FLT1 and Inflammation
 Nervous System Diseases Antibodies  >50 publications with FLT1 and Nervous System Diseases
 Adenocarcinoma Antibodies  >40 publications with FLT1 and Adenocarcinoma
 Kidney Diseases Antibodies  >37 publications with FLT1 and Kidney Diseases
 Brain Diseases Antibodies  >37 publications with FLT1 and Brain Diseases
 Heart Diseases Antibodies  >36 publications with FLT1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1049 publications with FLT1 and Vascular
 Blood Antibodies  >613 publications with FLT1 and Blood
 Placenta Antibodies  >347 publications with FLT1 and Placenta
 Embryonic Tissue Antibodies  >127 publications with FLT1 and Embryonic Tissue
 Muscle Antibodies  >88 publications with FLT1 and Muscle
 Bone Antibodies  >81 publications with FLT1 and Bone
 Liver Antibodies  >74 publications with FLT1 and Liver
 Kidney Antibodies  >73 publications with FLT1 and Kidney
 Lung Antibodies  >68 publications with FLT1 and Lung
 Brain Antibodies  >61 publications with FLT1 and Brain
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