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anti-FNDC5 antibody :: Rabbit FNDC5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS769410
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FNDC5, Polyclonal Antibody

★Popular Item★
 Also Known As   

FNDC5 Rabbit Polyclonal

 Product Synonym Names    FNDC5, FRCP2, Irisin
 Product Gene Name   

anti-FNDC5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS769410 Technical Datasheet    Technical Datasheet PDF
 OMIM    611906
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse; other species are not tested.
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 Specificity    Please decide the specificity by homology
 Purity/Purification    >=95% as determined by SDS-PAGE
Immunogen Affinity Purified
 Form/Format    Liquid
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 Immunogen    Fibronectin type III domain containing 5
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH 7.3
 Calculated MW    20 kDa
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 Preparation and Storage    Store at -20C for 24 months (Avoid repeated freeze / thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FNDC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FNDC5 antibody

   Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
 Applications Tested/Suitable for anti-FNDC5 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

 Application Notes for anti-FNDC5 antibody    WB : 1:200-1:2000
IP :1:200-1:100
IHC : 1:20-1:200
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 Immunohistochemistry of anti-FNDC5 antibody    Immunohistochemistry of paraffin-embedded human skeletal muscle slide using MBS769410( FNDC5 Antibody) at dilution of 1:50
anti-FNDC5 antibody Immunohistochemistry (IHC) image
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 SDS-PAGE of anti-FNDC5 antibody    mouse placenta tissue were subjected to SDS PAGE followed by western blot with MBS769410 (FNDC5 antibody) at dilution of 1:1000
anti-FNDC5 antibody SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for FNDC5. It may not necessarily be applicable to this product.
 NCBI GI #    511094000
 NCBI GeneID    252995
 NCBI Accession #    NP_715637.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_153756.2 [Other Products]
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 UniProt Secondary Accession #    Q6P6D9; Q7Z676; A6NMC9; D3DPQ6 [Other Products]
 UniProt Related Accession #    Q8NAU1 [Other Products]
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 NCBI Official Full Name    fibronectin type III domain-containing protein 5 isoform 2 preproprotein
 NCBI Official Synonym Full Names    fibronectin type III domain containing 5
 NCBI Official Symbol    FNDC5 [Similar Products]
 NCBI Official Synonym Symbols   
FRCP2; irisin
[Similar Products]
 NCBI Protein Information    fibronectin type III domain-containing protein 5
 UniProt Protein Name    Fibronectin type III domain-containing protein 5
 UniProt Synonym Protein Names   
Fibronectin type III repeat-containing protein 2
 Protein Family    Fibronectin type III domain-containing protein
 UniProt Gene Name    FNDC5 [Similar Products]
 UniProt Synonym Gene Names    FRCP2 [Similar Products]
 UniProt Entry Name    FNDC5_HUMAN
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 NCBI Summary for FNDC5    This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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 UniProt Comments for FNDC5    FNDC5: Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: endoplasmic reticulum; extracellular region; integral to membrane; peroxisomal membrane; plasma membrane

Molecular Function: hormone activity

Biological Process: response to muscle activity
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 Research Articles on FNDC5    1. Data suggest that irisin may be involved in the regulation of endothelial function in obesity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FNDC5 antibodyDiseases associated with anti-FNDC5 antibody
 Reference Product  PubMed Publications
 UCP1 antibody  >17 publications with FNDC5 and UCP1
 FGF21 antibody  >15 publications with FNDC5 and FGF21
 PRDM16 antibody  >5 publications with FNDC5 and PRDM16
 ADIPOQ antibody  >5 publications with FNDC5 and ADIPOQ
 TMEM26 antibody  >3 publications with FNDC5 and TMEM26
 Disease Name  Pubmed Publications
 Weight Loss Antibodies  >16 publications with FNDC5 and Weight Loss
 Inflammation Antibodies  >14 publications with FNDC5 and Inflammation
 Necrosis Antibodies  >9 publications with FNDC5 and Necrosis
 Liver Diseases Antibodies  >8 publications with FNDC5 and Liver Diseases
 Kidney Diseases Antibodies  >7 publications with FNDC5 and Kidney Diseases
 Disease Models, Animal Antibodies  >6 publications with FNDC5 and Disease Models, Animal
 Nervous System Diseases Antibodies  >5 publications with FNDC5 and Nervous System Diseases
 Weight Gain Antibodies  >3 publications with FNDC5 and Weight Gain
 Rhabdomyosarcoma Antibodies  >2 publications with FNDC5 and Rhabdomyosarcoma
 Neurobehavioral Manifestations Antibodies  >2 publications with FNDC5 and Neurobehavioral Manifestations
Organs/Tissues associated with anti-FNDC5 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >129 publications with FNDC5 and Blood
 Muscle Antibodies  >128 publications with FNDC5 and Muscle
 Heart Antibodies  >31 publications with FNDC5 and Heart
 Brain Antibodies  >25 publications with FNDC5 and Brain
 Vascular Antibodies  >14 publications with FNDC5 and Vascular
 Kidney Antibodies  >11 publications with FNDC5 and Kidney
 Embryonic Tissue Antibodies  >9 publications with FNDC5 and Embryonic Tissue
 Ovary Antibodies  >5 publications with FNDC5 and Ovary
 Lung Antibodies  >4 publications with FNDC5 and Lung
 Intestine Antibodies  >2 publications with FNDC5 and Intestine
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